Nov 17, 2019

What are the threats to successful brain and cognitive aging?

Neurobiology of Aging
Michela GallagherPeter R Rapp


The structure and function of the brain change over the life span. Aged brains often accumulate pathologic lesions, such as amyloid plaques and tau tangles, which lead to diminished cognitive ability in some, but not all, individuals. The basis of this vulnerability and resilience is unclear. Age-related changes can alter neural firing patterns and ability to form new memories. Risk factors for cognitive decline include male sex and apolipoprotein E genotype. Physical activity seems to be protective against cognitive decline. Longitudinal studies have shown that, although the onset of amyloid pathology and associated cognitive decline can vary greatly, once it begins, the rate of deposition is similar among affected individuals. This session of the Cognitive Aging Summit III explored fixed and modifiable factors that can threaten cognitive function in aging adults and approaches to modulate at least some of these risks.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Longitudinal Studies
Ability to Perform Cognitive Activity
Tau Proteins
Impaired Cognition

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Related Papers

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
William S KremenR S Wilson
Journal of Psychosocial Nursing and Mental Health Services
Kristine N Williams, Susan Kemper
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Suzanne CraftKristine Yaffe
© 2020 Meta ULC. All rights reserved