What are the treatment options for patients with severe Alzheimer's disease?

CNS Drugs
Thierry VoisinBruno Vellas

Abstract

By some estimates moderate-to-severe Alzheimer's disease accounts for 50% of all patients with Alzheimer's disease. However, there are numerous issues that remain to be resolved in the management of patients with more advanced Alzheimer's disease. The first prospective, randomised, controlled trial of the cholinesterase inhibitor donepezil in more advanced Alzheimer's disease has reported quite encouraging results, with further studies being undertaken. Post-hoc analyses of rivastigmine and galantamine in patients with more advanced Alzheimer's disease have supported the hypothesis that acetylcholinesterase inhibitors are likely be efficacious in this subgroup. Memantine, a glutamate NMDA receptor antagonist, is newly licensed in Europe for the treatment of more advanced Alzheimer's disease and will provide the first non-cholinesterase inhibitor option for the treatment of Alzheimer's disease. The combination of donepezil and memantine has been shown to have superior efficacy than donepezil alone in this severe Alzheimer's disease subgroup, potentially supporting a role for dual treatment in more advanced Alzheimer's disease. Further studies of all aspects of more advanced Alzheimer's disease are clearly needed. The problems of...Continue Reading

References

Apr 24, 1999·BMJ : British Medical Journal·T Bayer
Apr 24, 1999·BMJ : British Medical Journal·A Berger
Apr 27, 1999·JAMA : the Journal of the American Medical Association·K L DavisV Haroutunian
May 15, 1999·Dementia and Geriatric Cognitive Disorders·A BurnsL T Friedhoff
Mar 21, 2001·Methods and Findings in Experimental and Clinical Pharmacology·H OguraY Yamanishi
Jul 24, 2001·International Journal of Geriatric Psychiatry·B WinbladD Wilkinson
Aug 15, 2001·Neurology·B WinbladUNKNOWN Donepezil Nordic Study Group
Aug 29, 2001·Neurology·H FeldmanUNKNOWN Donepezil MSAD Study Investigators Group
Feb 5, 2003·Dementia and Geriatric Cognitive Disorders·Rafael BlesaSusanne Schwalen
Apr 4, 2003·The New England Journal of Medicine·Barry ReisbergUNKNOWN Memantine Study Group
May 22, 2003·Journal of the American Geriatrics Society·Howard FeldmanUNKNOWN Donepezil MSAD Study Investigators Group
Sep 16, 2003·International Journal of Geriatric Psychiatry·Roy W Jones

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Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Wenming LiYifan Han
Nov 18, 2009·Psychological Medicine·H M MohrR Grabhorn
Apr 18, 2013·Psychological Medicine·A Riecher-RösslerUNKNOWN EUFEST Study Group
Dec 18, 2013·Development and Psychopathology·Patrick T Davies, Meredith J Martin
Feb 12, 2010·Social Cognitive and Affective Neuroscience·Alfonso Barrós-LoscertalesCésar Avila
Feb 24, 2006·Alzheimer Disease and Associated Disorders·Roger Bullock
Jun 19, 2013·Journal of Neurosurgery. Pediatrics·Dario J EnglotKurtis I Auguste
Jul 16, 2011·International Journal of Alzheimer's Disease·Andrea GuerraFlorinda Ferreri
Apr 28, 2006·Journal of Pharmaceutical Sciences·Bianca M Liederer, Ronald T Borchardt
Sep 18, 2007·Progress in Neurobiology·Paolo M RossiniJohn Polich
Oct 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nathan HerrmannPaul G Lysy
Jun 30, 2006·La Revue de médecine interne·C VantelonM-J Kergoat
Apr 28, 2005·Expert Review of Neurotherapeutics·Ian Hindmarch
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Matthew J BellizziHarris A Gelbard
Mar 19, 2009·Transcultural Psychiatry·Annette Leibing
Mar 8, 2005·PharmacoEconomics·Greg L Plosker, Katherine A Lyseng-Williamson

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