What bio technologists knew all along...?

Journal of Theoretical Biology
H V Westerhoff, D B Kell

Abstract

Qualitative, trial-and-error methods designed to increase the flux to desirable biotechnological products have led to new technologies and vast improvements in existing ones. However, these methods now appear in many cases to have approached their limit. In addition, there is a strong feeling in industry that much of the recent boom in academic knowledge of biochemistry and molecular biology passes biotechnology by, simply because one cannot evaluate the implications of molecular kinetics for the functioning of the producer organisms as a whole. New methods, or more rational methods, are called for. One, aimed at increasing only the concentration of a single metabolite by site-directed mutagenesis is developed here.

Citations

Jan 19, 2012·PLoS Computational Biology·Kyung H Kim, Herbert M Sauro
Apr 15, 2016·Journal of the Royal Society, Interface·Fei HeHans V Westerhoff
Apr 1, 1999·Biotechnology and Bioengineering·B N KholodenkoJ Schwaber
Feb 19, 2008·Journal of Mathematical Biology·Hans V WesterhoffJacky L Snoep
Nov 5, 2002·Trends in Genetics : TIG·Douglas B Kell
Oct 7, 2004·Biophysical Journal·Liqing WangVassily Hatzimanikatis
Mar 23, 2011·Plant Science : an International Journal of Experimental Plant Biology·Leighton Pritchard, Paul Birch

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