What bothers lung cancer patients the most? A prospective, longitudinal electronic patient-reported outcomes study in advanced non-small cell lung cancer

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Thomas W LeBlancAmy P Abernethy

Abstract

Patients with advanced non-small cell lung cancer (aNSCLC) face a significant symptom burden. Little is known about the frequency and severity of symptoms over time, so we longitudinally characterized patients' symptoms using the Patient Care Monitor (PCM) version 2.0, an electronic symptom-assessment tool. Ninety-seven patients with aNSCLC completed the PCM at up to four clinic visits. We analyzed symptom data by incidence, severity, type (functional vs. nonfunctional), proximity to death, and cancer anorexia-cachexia syndrome status (CACS). Functional concerns predominated, even in the non-CACS group. Average severity among the top 5 symptoms was worse for functional than nonfunctional items (mean difference 0.62, 95% CI 0.22-1.01, P = 0.003). Severe dyspnea and fatigue were the most prevalent nonfunctional symptoms; moderate/severe dyspnea was reported by at least 29% of patients, and fatigue by over 50%. Depression was reported infrequently, with over half of patients at each visit reporting "none"; moderate or severe depression was reported in only 2.5-9.3 and 3.4-6.2% of patients, respectively. The average number of moderate/severe symptoms increased with proximity to death; 84% reported moderate/severe fatigue in the las...Continue Reading

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Citations

Dec 27, 2015·Journal of Pain and Symptom Management·Gregory P SamsaAmy P Abernethy
Sep 19, 2015·Journal of Palliative Medicine·Grace Su Yin PangPatricia Soek Hui Neo
Feb 8, 2018·The American Journal of Hospice & Palliative Care·Grace Meijuan YangYin Bun Cheung
Apr 24, 2018·Oncology Nursing Forum·Sharyn Carrasco, Lene Symes
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Apr 2, 2016·Current Treatment Options in Oncology·Divya ChandrasekarKavitha Ramchandran
Feb 6, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Melisa L WongChristine Miaskowski
Dec 14, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Seyyed Mohammad Reza Kazemi-BajestaniVickie E Baracos
Jun 17, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kimlin Tam Ashing, Marshalee George
Jun 1, 2016·Lung Cancer Management·Rebecca H Lehto
Nov 30, 2019·Journal of Pain and Symptom Management·Maureen L SaphireAmy J Davidoff

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