Feb 18, 2017

What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?

The New Phytologist
Emily B JosephsStephen I Wright

Abstract

Contents 21 I. 21 II. 22 III. 24 IV. 25 V. 29 30 References 30 SUMMARY: Understanding the evolutionary forces that shape genetic variation within species has long been a goal of evolutionary biology. Integrating data for the genetic architecture of traits from genome-wide association mapping studies (GWAS) along with the development of new population genetic methods for identifying selection in sequence data may allow us to evaluate the roles of mutation-selection balance and balancing selection in shaping genetic variation at various scales. Here, we review the theoretical predictions for genetic architecture and additional signals of selection on genomic sequence for the loci that affect traits. Next, we review how plant GWAS have tested for the signatures of various selective scenarios. Limited evidence to date suggests that within-population variation is maintained primarily by mutation-selection balance while variation across the landscape is the result of local adaptation. However, there are a number of inherent biases in these interpretations. We highlight these challenges and suggest ways forward to further understanding of the maintenance of variation.

  • References121
  • Citations8

Mentioned in this Paper

Genome-Wide Association Study
Genome
Genome Assembly Sequence
Equilibrium
Genomics
Adaptation
Quantitative Trait, Heritable
Local
Species
Genetic Predisposition to Disease

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