What can imaging tell us about physiology? Lung growth and regional mechanical strain.

Journal of Applied Physiology
Connie C W Hsia, M H Tawhai

Abstract

The interplay of mechanical forces transduces diverse physico-biochemical processes to influence lung morphogenesis, growth, maturation, remodeling and repair. Because tissue stress is difficult to measure in vivo, mechano-sensitive responses are commonly inferred from global changes in lung volume, shape, or compliance and correlated with structural changes in tissue blocks sampled from postmortem-fixed lungs. Recent advances in noninvasive volumetric imaging technology, nonrigid image registration, and deformation analysis provide valuable tools for the quantitative analysis of in vivo regional anatomy and air and tissue-blood distributions and when combined with transpulmonary pressure measurements, allow characterization of regional mechanical function, e.g., displacement, strain, shear, within and among intact lobes, as well as between the lung and the components of its container-rib cage, diaphragm, and mediastinum-thereby yielding new insights into the inter-related metrics of mechanical stress-strain and growth/remodeling. Here, we review the state-of-the-art imaging applications for mapping asymmetric heterogeneous physical interactions within the thorax and how these interactions permit as well as constrain lung growt...Continue Reading

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Citations

May 5, 2012·Journal of Applied Physiology·G Kim Prisk, H Thomas Robertson
Oct 30, 2012·Journal of Applied Physiology·D Merrill DaneConnie C W Hsia
Jun 27, 2013·PloS One·Richard E JacobDaniel R Einstein
Apr 29, 2014·IEEE Transactions on Medical Imaging·Arnold D GomezEdward W Hsu
Aug 31, 2013·Journal of Applied Physiology·Nenad FilipovicAkira Tsuda

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