PMID: 2484377Jan 1, 1989Paper

What can in vitro methods tell us about mineral availability?

Biological Trace Element Research
P E Johnson

Abstract

In vitro studies of mineral bioavailability are useful because they are faster and less expensive than in vivo studies and because they offer better control over experimental variables. Selection of conditions for in vitro assays of mineral availability is arbitrary. Conditions vary widely among laboratories and with the mineral of interest. Absorption takes place in vivo under conditions that allow ongoing influx and efflux of nutrients and digestive secretions. Conditions in the digestive tract respond to the bulk and nutrient composition of a meal. How does one reproduce these conditions in a closed in vitro system? Correlations between in vivo and in vitro assays may depend on choice of conditions for in vivo studies. Studies of mineral bioavailability from soils have developed to the point that mathematical models have been developed that predict the bioavailability of various minerals to plants under field conditions. Definition of such a model for mineral bioavailability to animals or humans will probably be more difficult to achieve. More information is needed on the nature of nonmineral components of foods and how they interact with minerals.

References

Feb 1, 1979·Digestive Diseases and Sciences·J R MalageladaW H Summerskill
Sep 1, 1977·Gut·D S Grimes, J Goddard
Jul 1, 1978·Journal of Agricultural and Food Chemistry·P E Johnson, G W Evans
Jul 1, 1976·The American Journal of Clinical Nutrition·E Björn-RasmussenB Arvidsson
Mar 1, 1977·Journal de médecine de Bordeaux et du Sud-Ouest·E Giroux, N J Prakash
Apr 1, 1977·The American Journal of Clinical Nutrition·L HallbergR Suwanik
May 1, 1987·Digestive Diseases and Sciences·W J Snape
Nov 1, 1986·The Journal of Nutrition·R A Wapnir, L Stiel
Jul 1, 1973·Physiological Reviews·W Forth, W Rummel
Aug 1, 1983·The Journal of Nutrition·K L WrickL R Hackler
Mar 1, 1984·Digestive Diseases and Sciences·C EeckhoutI De Wever
May 1, 1983·The British Journal of Nutrition·M GilloolyF Mayet
Feb 1, 1964·The Journal of Nutrition·P Vohra, H Kratzer

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Citations

Jan 1, 1991·Critical Reviews in Food Science and Nutrition·M TorreF Saura-Calixto

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