What can lipidomics tell us about the pathogenesis of Alzheimer disease?

Biological Chemistry
Yanhui XiangGuanghou Shui

Abstract

Lipids serve many distinct functions in cellular homeostasis such as membrane organization, as a platform for membrane function and protein/protein or protein/lipid interaction, energy storage, as well as secondary messengers in signal transduction. Perturbations in lipid homeostasis may result in abnormal cellular function. Alzheimer's disease (AD) is a neurodegenerative disorder in which the brain represents the primary site of pathology. While there is a plethora of previous work pertaining to AD pathogenesis, the precise mechanism of the disease is still not well-understood. Recent waves of technological advances in the realm of lipidomics have enabled scientists to look at AD pathogenesis from a previously unexplored perspective, and studies have revealed extensive lipid aberrations are implicated in the disease pathology. Herein, we review the critical lipids alternations, which affect amyloid plaque and neurofibrillary tangles formation and accumulation, as well as lipid aberrations related to neuronal and synaptic dysfunction in cells and animal models. We also summarize lipid abnormalities observed in the human cerebrospinal fluid (CSF), as well as other circulating fluids including plasma and serum in association with...Continue Reading

References

Dec 1, 1995·Human Molecular Genetics·D CampionS Tardieu
Jul 1, 1996·Human Molecular Genetics·R SherringtonP H St George-Hyslop
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S J HaugabookC B Eckman
Jul 17, 2001·Current Opinion in Cell Biology·A SimonsenH Stenmark
Feb 19, 2002·Neurobiology of Disease·Suzanne WahrleTodd E Golde
Jul 3, 2003·Annals of Neurology·Xianlin HanDavid M Holtzman
Jan 13, 2004·The Journal of Biological Chemistry·Naoya SawamuraMakoto Michikawa
Jun 1, 1993·Trends in Cell Biology·S E PfeifferR Bansal
Oct 7, 2004·Neurobiology of Aging·Anna WalterJochen Klein
Oct 18, 2005·Nature Cell Biology·Marcus O W GrimmTobias Hartmann
Apr 22, 2006·The Biochemical Journal·Mike P WilliamsonTetsuo Asakura
May 25, 2006·Journal of Cellular Biochemistry·Sang-Il KimYoung-Gyu Ko
Jun 29, 2006·Annals of the New York Academy of Sciences·Denham Harman
Feb 27, 2007·Biochimica Et Biophysica Acta·Katsuhiko Yanagisawa
May 6, 2008·Neurobiology of Aging·Michelle M MielkeMichelle C Carlson
May 10, 2008·Molecular Neurobiology·Matthias Eckhardt
May 16, 2008·The Journal of Biological Chemistry·Satoko OsawaYasuo Ihara
Jan 10, 2009·Experimental Cell Research·Thomas FalguièresJean Gruenberg
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Feb 1, 2011·Annals of Neurology·Jin Chu, Domenico Praticò
Mar 31, 2011·Nature Reviews. Neuroscience·Gilbert Di Paolo, Tae-Wan Kim
Jan 20, 2012·Journal of Alzheimer's Disease : JAD·Valery FilippovPenelope J Duerksen-Hughes
Jul 5, 2012·Annals of the New York Academy of Sciences·Paola GambaGabriella Leonarduzzi
May 3, 2013·Journal of Alzheimer's Disease : JAD·Luigi IulianoGianfranco Spalletta
Aug 24, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Sin Man Lam, Guanghou Shui
Jan 25, 2014·Acta Neuropathologica Communications·Timothy A CouttasAnthony S Don
Mar 13, 2014·Nature Medicine·Mark MapstoneHoward J Federoff

❮ Previous
Next ❯

Citations

Jun 22, 2017·Journal of Urban Health : Bulletin of the New York Academy of Medicine·David M KernGenevieve Pham-Kanter
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Anne Katrine BerglandDag Aarsland
Sep 4, 2018·BioMed Research International·Yingrong ChenLicheng Dai
Nov 21, 2018·Frontiers in Molecular Neuroscience·Gernot FruhmannChristophe Cullin
Nov 28, 2017·Metabolomics : Official Journal of the Metabolomic Society·Jia TuZheng-Jiang Zhu
Dec 4, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Giulia Cisbani, Richard P Bazinet
Apr 18, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Angélica María Sabogal-GuáquetaGloria Patricia Cardona-Gómez

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
imaging techniques

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
A E RoherS Gracon
Seikagaku. The Journal of Japanese Biochemical Society
Akihiko Takashima
© 2021 Meta ULC. All rights reserved