What can rhythm control therapy contribute to prognosis in atrial fibrillation?

Heart
Sascha RolfG Hindricks

Abstract

Atrial fibrillation (AF) is a global healthcare problem of growing prevalence and major significance. The consequences of AF include an increased rate of death, stroke and heart failure. Theoretically, a therapeutic strategy aiming at restoration and maintenance of sinus rhythm should offset the prognosis impairment associated with AF. However, these expectations were disproven in large randomised controlled trials comparing conventional antiarrhythmic drugs for rhythm control with conventional rate control. These apparently contradictory findings suggest that rhythm control strategies require better therapeutic instruments. These improvements may involve drugs and/or interventions with optimised risk-benefit profile and which also appreciate the specific atrial pathology and the patient's comorbidities. This article addresses important aspects of rhythm control strategies, which may have the potential of a beneficial contribution to the prognosis of AF patients.

References

Dec 6, 2002·The New England Journal of Medicine·D G WyseUNKNOWN Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
Jun 21, 2008·The New England Journal of Medicine·Denis RoyUNKNOWN Atrial Fibrillation and Congestive Heart Failure Investigators
Feb 14, 2009·The New England Journal of Medicine·Stefan H HohnloserUNKNOWN ATHENA Investigators
Nov 28, 2009·BMC Medicine·Paulus Kirchhof
Sep 18, 2012·Pacing and Clinical Electrophysiology : PACE·Saurav ChatterjeeShamik Aikat
Oct 26, 2012·The New England Journal of Medicine·Jens Cosedis NielsenPeter Steen Hansen
Sep 24, 2013·The American Journal of Medicine·Nasir ShariffAli Ahmed
Feb 6, 2014·JAMA : the Journal of the American Medical Association·Nassir F MarroucheJohannes Brachmann
Feb 20, 2014·JAMA : the Journal of the American Medical Association·Carlos A MorilloUNKNOWN RAAFT-2 Investigators
Feb 25, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marco ScaglioneFiorenzo Gaita
Apr 8, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Meiso HayashiWataru Shimizu
Apr 26, 2014·Circulation Research·Christopher E Woods, Jeffrey Olgin
Aug 7, 2014·Expert Review of Cardiovascular Therapy·Federico GuerraAlessandro Capucci
Aug 26, 2014·Circulation. Arrhythmia and Electrophysiology·Sascha RolfChristopher Piorkowski
Sep 30, 2014·Circulation. Arrhythmia and Electrophysiology·Matteo AnselminoFiorenzo Gaita

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