What can stimulus polarity and interphase gap tell us about auditory nerve function in cochlear-implant recipients?

Hearing Research
Michelle L HughesErin Glickman

Abstract

Modeling studies suggest that differences in neural responses between polarities might reflect underlying neural health. Specifically, large differences in electrically evoked compound action potential (eCAP) amplitudes and amplitude-growth-function (AGF) slopes between polarities might reflect poorer peripheral neural health, whereas more similar eCAP responses between polarities might reflect better neural health. The interphase gap (IPG) has also been shown to relate to neural survival in animal studies. Specifically, healthy neurons exhibit larger eCAP amplitudes, lower thresholds, and steeper AGF slopes for increasing IPGs. In ears with poorer neural survival, these changes in neural responses are generally less apparent with increasing IPG. The primary goal of this study was to examine the combined effects of stimulus polarity and IPG within and across subjects to determine whether both measures represent similar underlying mechanisms related to neural health. With the exception of one measure in one group of subjects, results showed that polarity and IPG effects were generally not correlated in a systematic or predictable way. This suggests that these two effects might represent somewhat different aspects of neural healt...Continue Reading

Citations

Apr 6, 2019·Journal of the Association for Research in Otolaryngology : JARO·Kelly N Jahn, Julie G Arenberg
Jun 5, 2019·Journal of the Association for Research in Otolaryngology : JARO·Tobias GoehringRobert P Carlyon
Aug 3, 2019·Trends in Hearing·Kelly N Jahn, Julie G Arenberg
Feb 6, 2020·Journal of the Association for Research in Otolaryngology : JARO·Quentin MesnildreyOlivier Macherey
Apr 29, 2020·Journal of the Association for Research in Otolaryngology : JARO·Kara C Schvartz-LeyzacBryan E Pfingst
Feb 2, 2019·Journal of the Association for Research in Otolaryngology : JARO·Emily R SpitzerMichelle L Hughes
Oct 28, 2020·Journal of the Association for Research in Otolaryngology : JARO·Tim BrochierRobert P Carlyon
Feb 2, 2021·Frontiers in Psychology·Colette M McKay
Nov 6, 2020·Journal of the Association for Research in Otolaryngology : JARO·Tim BrochierRobert P Carlyon
May 25, 2021·Trends in Hearing·Kelly C JohnsonMatthew J Goupell
Aug 18, 2021·Journal of Neural Engineering·Ashwati KrishnanShawn K Kelly

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