What can we learn about asthma from studying occupational asthma?

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
A J Frew

Abstract

To review the clinical features and underlying mechanisms of occupational asthma in an attempt to glean insights into various other forms of asthma. Published literature, including consensus guidelines on diagnosis and management of occupational asthma. This article represents a synthesis of these data sources and the opinion of the author. Occupational asthma may be caused by a variety of mechanisms, including both IgE-dependent and non-IgE-dependent immunological processes. IgE-dependent mechanisms are responsible for reactions to all high-molecular-weight occupational antigens and to some but not all low-molecular-weight antigens. Factors in sensitization and onset include the general genetic predisposition to make IgE and the specific responsiveness of the individual to particular allergens. Once sensitized, the main factor that influences the onset of symptoms is the degree of exposure. In general, the higher the level of exposure, the more likely the sensitized person is to develop asthma. Occupational asthma can be induced by a variety of agents that appear to use different mechanisms to affect the airway. Studies of the remission of occupational asthma indicate that resolution is a slow process. However, the study of oc...Continue Reading

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Citations

Jun 4, 2004·Current Allergy and Asthma Reports·Virginia L Calder, Peter M Lackie
Jul 13, 2011·Journal of Allergy·Berran Yucesoy, Victor J Johnson
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
Dec 14, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Aarif Omar EifanTezer Kutluk

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