What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?

Immunological Reviews
P Klenerman, R M Zinkernagel

Abstract

The role of cytotoxic T lymphocytes (CTL) in human immunodeficiency virus (HIV) infection remains elusive. Since the discovery 10 years ago of high levels of specific CTL in this disease, some have argued that they play an important role in virus control, others that they drive disease progression through destruction of T helper cells, and others still that they play no obvious role at all. By contrast, the central role of CTL in murine lymphocytic choriomeningitis virus (LCMV) infection has been very clearly worked out through the use of in vivo depletion and adoptive transfer experiments, as well as knockout and transgenic mice. To interpret the possible roles for CTL in HIV, we have therefore made a comparison between what is known about CTL and their interaction with virus-infected cells in these two infections. This illustrates a potential critical role for these cells in both control of HIV replication and immune-mediated pathology, but one that is highly dependent on virus dose, distribution and dynamics.

References

Jan 1, 1975·Intervirology·S N BanerjeeW E Rawls
Aug 1, 1992·Current Opinion in Immunology·R M Zinkernagel, H Hengartner
Jan 1, 1992·Springer Seminars in Immunopathology·R M ZinkernagelH Hengartner
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G PantaleoA S Fauci
Dec 12, 1991·Nature·R M Zinkernagel, H Hengartner
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T AebischerH Hengartner
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P A MossJ I Bell
May 1, 1988·The Journal of Experimental Medicine·T P LeistR M Zinkernagel
Jan 1, 1987·Current Topics in Microbiology and Immunology·C J PetersJ G Barrera Oro
May 1, 1988·The Journal of Experimental Medicine·R Ahmed, M B Oldstone
Feb 1, 1987·European Journal of Immunology·H PircherR M Zinkernagel
Jan 1, 1980·Advances in Immunology·M J BuchmeierM B Oldstone
Aug 1, 1995·Immunological Reviews·D KägiH Hengartner
Aug 1, 1995·Current Opinion in Immunology·J T Safrit, R A Koup
Aug 1, 1995·Current Opinion in Immunology·R M Zinkernagel
Apr 1, 1995·Journal of Virology·D Moskophidis, R M Zinkernagel
Jan 1, 1995·Advances in Experimental Medicine and Biology·R M Zinkernagel
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·P A MossJ I Bell
Jan 1, 1995·Immunity·S C Jameson, M J Bevan
Jan 26, 1995·The New England Journal of Medicine·G PantaleoL K Schrager

❮ Previous
Next ❯

Citations

Mar 10, 2001·Reviews in Medical Virology·F LechnerP Klenerman
Jul 16, 2002·Pathologie-biologie·Paul KlenermanAnnette Oxenius
Oct 26, 2001·Current Opinion in Immunology·Z Grossman, W E Paul
Feb 5, 2002·Microbes and Infection·Paul KlenermanGillian Harcourt
Jan 10, 2001·The Journal of Experimental Medicine·P J GoulderC Brander
Sep 6, 2000·Proceedings. Biological Sciences·R A ArnaoutD Wodarz
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·P AndréV Lotteau
Oct 2, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Dominik Wodarz
May 19, 2000·Journal of Theoretical Biology·R A Arnaout, M A Nowak
Nov 18, 2015·Journal of Immunology Research·Gennady BocharovAndreas Meyerhans
Jun 17, 2003·Nature Medicine·Juthathip MongkolsapayaGavin Screaton
Nov 13, 2001·International Journal of Experimental Pathology·M LucasP Klenerman
Oct 31, 2018·Frontiers in Immunology·Elizabeth M KolawoleBrian D Evavold
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke FiratGabriele Niedermann
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke FiratGabriele Niedermann
Aug 24, 2021·Frontiers in Microbiology·Carla S CoffinTomasz I Michalak

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.