What can we learn from leukemia as for the process of lineage commitment in hematopoiesis?

International Reviews of Immunology
C A Schmidt, G K Przybylski

Abstract

Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chronic myeloid leukemia (CML) in the blast crisis may switch to acute lymphoblastic leukemia (ALL) and as a result of the chemotherapy ALL may converse to acute myeloid leukemia (AML). Furthermore, a substantial portion of leukemia cases, named acute mixed-lineage leukemia (AMLL), show simultaneous expression of both myeloid and lymphoid antigens. Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements, correlating with myeloid-lymphoid immunophenotype in AMLL, support the hypothesis of lineage infidelity of early progenitor cells, rather than the aberrant antigen expression. Based on a detailed characterization of AMLL we present a modified model of a "common myeloid/lymphoid progenitor cell". This hypothetical very early hematopoietic progenitor cell shows a transient expression of myeloid and B- or T-lymphoid antigen and may also have rearranged its Ig and/or TCR genes. Subsequently, myeloid or lymphoid ...Continue Reading

References

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Citations

Oct 31, 2003·Experimental Hematology·Claudia D BaldusAlbert de la Chapelle
Jan 7, 2010·Blood Cells, Molecules & Diseases·Tania Aparecida Rodrigues FernandesMaria Helena Stangler Kraemer
Jun 21, 2005·Veterinary Immunology and Immunopathology·M J WilkersonA Avery
Nov 16, 2013·Leukemia Research·Nobutaka KiyokawaAkira Ohara
Apr 18, 2015·Journal of Hematology & Oncology·Axel SchulenburgPeter Valent
Jun 23, 2004·Critical Reviews in Oncology/hematology·Stewart Sell
Mar 26, 2002·Nature Reviews. Immunology·Yoshimoto Katsura
Apr 9, 2011·The Korean journal of laboratory medicine·Borae G ParkJung-Hee Lee
Mar 25, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stewart Sell
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine StrehlShai Izraeli

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