What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?

Aquatic Toxicology
Kristoffer DalhoffNina Cedergreen

Abstract

Azole fungicides (imidazoles and triazoles) are known to function synergistically with several compounds, especially with pyrethroid insecticides, most likely by inhibiting cytochrome P450. Different azole fungicides have been shown to differ in their synergistic potentials usually with the imidazoles being stronger synergists than the triazoles. This study investigated whether the toxicokinetic and toxicodynamic (TKTD) properties of the imidazole prochloraz and triazole propiconazole can explain their different synergistic potential toward the freshwater macroinvertebrate Daphnia magna. Pulse exposure to external concentrations of propiconazole (1.4μM) and prochloraz (1.7μM) for 18h resulted in internal concentrations of 22.7 and 53.5μmolkg(-1)w.w. for propiconazole and prochloraz, respectively. This 2-fold difference in bioaccumulation corresponded very well with the observed 2.7-fold lower external EC50-estimate (7 days) for prochloraz compared to propiconazole. The estimated IC50 for the in vivo inhibition of cytochrome P450 (ECOD) activity, however, measured as transformation of 7-ethoxycoumarin into 7-hydroxycoumarin, was almost 500-fold higher for prochloraz (IC50: 0.011±0.002μM) compared to propiconazole (IC50: 4.9±0.06...Continue Reading

References

Mar 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J Snegaroff, J Bach
Aug 26, 1998·Mycoses·H Vanden Bossche, L Koymans
May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A M VinggaardJ C Larsen
May 15, 2001·Environmental Toxicology and Chemistry·K Kast-HutchesonG A LeBlanc
Jan 28, 2003·Ecotoxicology and Environmental Safety·Thomas FisherAmanda Callaghan
Jun 9, 2004·Drug Discovery Today·David F V LewisMaurice Dickins
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gerald T AnkleyVickie S Wilson
Aug 19, 2007·Integrated Environmental Assessment and Management·Jason B BeldenMichael J Lydy
Jun 16, 2009·Environmental Toxicology·Beatrice GagnaireJeanne Garric
Jan 16, 2010·Environmental Science and Pollution Research International·Katrine Banke Nørgaard, Nina Cedergreen
Apr 27, 2010·Zebrafish·Huw S JonesJ Kevin Chipman
Sep 24, 2010·Journal of Environmental Monitoring : JEM·Roman Ashauer, Beate I Escher
Jan 11, 2011·Aquatic Toxicology·Maj-Britt A BjergagerNina Cedergreen
Mar 4, 2011·Environmental Science & Technology·Tjalling JagerRoman Ashauer
Feb 6, 2013·PloS One·Reed M JohnsonMarion D Ellis

❮ Previous
Next ❯

Citations

Feb 2, 2017·Environmental Toxicology and Chemistry·Michele GottardiNina Cedergreen
Aug 29, 2017·Archives of Toxicology·Antonio F HernándezMarina Lacasaña
Jul 16, 2021·Environmental Toxicology and Pharmacology·Simone Caetani MachadoIsarita Martins
Apr 2, 2020·Environmental Science & Technology·Kristoffer DalhoffNina Cedergreen
Sep 14, 2017·Environmental Science & Technology·Nina CedergreenAndreas C Kretschmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.