What do patterns of genetic variability reveal about mitochondrial recombination?

Heredity
G A McVean

Abstract

Recent claims that patterns of genetic variability in human mitochondria show evidence for recombination, have provoked considerable argument and much correspondence concerning the quality of the data, the nature of the analyses, and the biological realism of mitochondrial recombination. While the majority of evidence now points towards a lack of effective recombination, at least in humans, the debate has highlighted how difficult the detection of recombination can be in genomes with unusual mutation processes and complex demographic histories. A major difficulty is the lack of consensus about how to measure linkage disequilibrium. I show that measures differ in the way they treat data that are uninformative about recombination, and that when just those pairwise comparisons that are informative about recombination are used, there is agreement between different statistics. In this light, the significant negative correlation between linkage disequilibrium and distance, in at least some of the data sets, is a real pattern that requires explanation. I discuss whether plausible mutational and selective processes can give rise to such a pattern.

References

Sep 27, 1991·Science·L VigilantA C Wilson
Jul 18, 1991·Nature·U GyllenstenA C Wilson
Jan 1, 1987·Nature·R L CannA C Wilson
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KanedaH Yonekawa
Nov 1, 1996·The Journal of Biological Chemistry·B ThyagarajanC Campbell
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·F Ankel-Simons, J M Cummins
Jul 1, 1997·American Journal of Human Genetics·N Howell
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·B J SavilleJ B Anderson
May 15, 1998·Molecular Biology and Evolution·J Maynard Smith, N H Smith
Mar 18, 1999·Journal of Molecular Evolution·G PesoleC Saccone
Apr 6, 1999·Proceedings. Biological Sciences·A Eyre-WalkerJ M Smith
Apr 6, 1999·Proceedings. Biological Sciences·E HagelbergD K Bowden
Dec 10, 1999·Nature·P SutovskyG Schatten
Apr 27, 2000·Trends in Ecology & Evolution·J Hey
Jul 15, 2000·Science·S S Abdool Karim
Jul 21, 2000·Proceedings. Biological Sciences·V MacaulayB Sykes
Nov 25, 2000·Human Molecular Genetics·O A KajanderH T Jacobs
Dec 15, 2000·American Journal of Human Genetics·J L ElsonN Howell
Dec 29, 2000·Nature·M IngmanU Gyllensten
Oct 19, 2001·Genetics·C Wiuf
Oct 25, 2001·Journal of Molecular Evolution·A Eyre-Walker, P Awadalla
Dec 1, 2001·Genetics·P Fearnhead, P Donnelly
Nov 25, 2003·Nature Reviews. Genetics·Michael P H Stumpf, Gilean A T McVean
Jun 1, 1968·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W G Hill, A Robertson

❮ Previous
Next ❯

Citations

Aug 30, 2002·Molecular Biology and Evolution·Francis M Jiggins
May 5, 2005·Proceedings. Biological Sciences·Benjamin GantenbeinFrançois Balloux
May 11, 2007·Proceedings. Biological Sciences·Andrey Tatarenkov, John C Avise
Aug 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thomas Städler, Lynda F Delph
May 11, 2004·Journal of Genetics·Evgeniy S Balakirev, Francisco J Ayala
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Andrea J BetancourtBrian Charlesworth
Jun 29, 2004·Fungal Genetics and Biology : FG & B·L P N M KroonW G Flier
May 17, 2006·Anaerobe·Youhanna S Sawires, J Glenn Songer
Nov 14, 2002·Annual Review of Genetics·David PosadaEdward C Holmes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular Biology and Evolution
Hideki Innan, Magnus Nordborg
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A Eyre-Walker
© 2022 Meta ULC. All rights reserved