What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?

Biochimie
Jože PungerčarIgor Krizaj

Abstract

Secreted phospholipases A2 (sPLA2s) form a widespread group of structurally-related enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids. In humans, nine catalytically active and two inactive sPLA2 proteins have been identified. These enzymes play diverse biological roles, including host defence against bacteria, parasites and viruses. Several of these endogenous sPLA2s may play a defensive role in viral infections, as they display in vitro antiviral activity by both direct and indirect mechanisms. However, endogenous sPLA2s may also exert an offensive and negative role, dampening the antiviral response or promoting inflammation in animal models of viral infection. Similarly, several exogenous sPLA2s, most of them from snake venoms and other animal venoms, possess in vitro antiviral activities. Thus, both endogenous and exogenous sPLA2s may be exploited for the development of new antiviral substances or as therapeutic targets for antagonistic drugs that may promote a more robust antiviral response. In this review, the antiviral versus proviral role of both endogenous and exogenous sPLA2s against various viruses including coronaviruses is presented....Continue Reading

References

Sep 22, 1995·The Journal of Biological Chemistry·B P KennedyW A Cromlish
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R C AloiaF C Jensen
Mar 1, 1997·Journal of Cellular Biochemistry·J ChenJ A Tischfield
Feb 12, 1998·The Journal of Infection·T J Nevalainen, W Losacker
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y WangR Thalmann
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·E VerpyC Petit
Jun 26, 1999·The Journal of Biological Chemistry·E ValentinG Lambeau
Sep 16, 1999·The Journal of Clinical Investigation·D FenardA Doglio
Feb 22, 2000·The Journal of Biological Chemistry·N SuzukiK Hanasaki
Nov 6, 2001·The Journal of Biological Chemistry·Rao S KoduriMichael H Gelb
Oct 1, 2003·Biochemistry·Morgane RouaultGérard Lambeau
Sep 21, 2004·Journal of Gastroenterology and Hepatology·Masamichi ItoToshiharu Ishii
Sep 9, 2005·The Biochemical Journal·Michiko MitsuishiMakoto Murakami
Sep 29, 2005·Biochimica Et Biophysica Acta·Seiko MasudaIchiro Kudo
Feb 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Britta BrüggerHans-Georg Kräusslich
Mar 8, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heikki T HuhtinenV Jukka O Laine
Oct 2, 2007·Toxicon : Official Journal of the International Society on Toxinology·Joze Pungercar, Igor Krizaj
Dec 22, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sophie LimouJean-François Zagury
Jan 8, 2008·Biochimica Et Biophysica Acta·Timo J NevalainenKieran F Scott
Apr 15, 2008·Annual Review of Biochemistry·Gérard Lambeau, Michael H Gelb
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara BalestrieriJonathan P Arm
Jul 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Caroline E von AllmenMartin F Bachmann
Apr 29, 2010·The Journal of Clinical Investigation·Hiroyasu SatoMakoto Murakami
Apr 29, 2010·The Journal of Clinical Investigation·Jessica EscoffierChristophe Arnoult

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.