What do unicellular organisms teach us about DNA methylation?

Trends in Parasitology
Hala Harony, Serge Ankri

Abstract

DNA methylation is an epigenetic hallmark that has been studied intensively in mammals and plants. However, knowledge of this phenomenon in unicellular organisms is scanty. Examining epigenetic regulation, and more specifically DNA methylation, in these organisms represents a unique opportunity to better understand their biology. The determination of their methylation status is often complicated by the presence of several differentiation stages in their life cycle. This article focuses on some recent advances that have revealed the unexpected nature of the epigenetic determinants present in protozoa. The role of the enigmatic DNA methyltransferase Dnmt2 in unicellular organisms is discussed.

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Citations

Jul 16, 2015·Integrative and Comparative Biology·Emily C DabeLeonid L Moroz

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