What do we (need to) know about the kinetic properties of nanoparticles in the body?

Regulatory Toxicology and Pharmacology : RTP
Werner I HagensAdriënne J A M Sips


Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.


May 1, 1992·American Journal of Respiratory Cell and Molecular Biology·J FerinD P Penney
Dec 1, 1990·The Journal of Pharmacy and Pharmacology·P JaniA T Florence
Dec 1, 1974·Environmental Health Perspectives·G Volkheimer
Jan 1, 1968·Digestion·G VolkheimerH Wendlandt
Apr 1, 1995·Journal of Pharmaceutical Sciences·D BazileM Veillard
Oct 1, 1994·Environmental Health Perspectives·G OberdörsterB E Lehnert
Nov 1, 1996·The Australasian Journal of Dermatology·M H TanP J Snitch
Apr 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·K OgawaraM Hashida
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·D W CagleL J Wilson
May 26, 1999·Journal of Drug Targeting·L AraujoJ Kreuter
Feb 15, 2001·Occupational and Environmental Medicine·K DonaldsonW MacNee
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K A JanesM J Alonso
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A NemmarB Nemery
Jan 26, 2002·Molecular Pharmacology·Bernd Moosmann, Christian Behl
Feb 23, 2002·Toxicology and Applied Pharmacology·Bellina VeronesiMarga Oortgiesen
May 11, 2002·The Proceedings of the Nutrition Society·Miranda C E LomerJonathan J Powell
May 16, 2002·Biomaterials·Antonietta M Gatti, Francesco Rivasi
May 23, 2002·Cellular and Molecular Life Sciences : CMLS·P CoyleA M Rofe
Sep 18, 2002·Nuclear Medicine and Biology·Li QingnuanLi Wenxin
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Günter OberdörsterChristopher Cox
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·James S BrownWilliam D Bennett
Dec 4, 2002·Advanced Drug Delivery Reviews·J SchulzK-P Wittern
Feb 14, 2003·Toxicology and Applied Pharmacology·Abderrahim NemmarBenoit Nemery
May 31, 2003·Science·Daniel R LarsonWatt W Webb
Jul 5, 2003·Environmental Health Perspectives·Sally S TinkleEric J Adkins
Oct 31, 2003·Biomaterials·Antonietta M Gatti
Jan 6, 2004·Nature Biotechnology·Paul Alivisatos
Jan 9, 2004·Expert Review of Vaccines·Charalambos D Partidos
Jan 22, 2004·Bioconjugate Chemistry·Byron BallouAlan S Waggoner
Mar 26, 2004·Nature Reviews. Drug Discovery·Mark R PrausnitzRobert Langer
Apr 15, 2004·International Journal of Pharmaceutics·A K Kohli, H O Alpar
May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·L L de ZwartA J A M Sips
Jun 19, 2004·Inhalation Toxicology·G OberdörsterC Cox
Aug 31, 2004·Journal of Materials Science. Materials in Medicine·Kirsten PetersEmanuela Monari
Aug 31, 2004·Journal of Materials Science. Materials in Medicine·A M GattiB Parisini
Oct 27, 2004·Journal of Nanoscience and Nanotechnology·Paul J A Borm, Wolfgang Kreyling
Feb 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jasmina LovrićDusica Maysinger
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jean-Christophe Olivier
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·J VermylenM F Hoylaerts

❮ Previous
Next ❯


Dec 21, 2013·Environmental Toxicology and Pharmacology·Berrin Tansel, Sharon C Surita
Jan 7, 2014·International Journal of Antimicrobial Agents·Robert P Allaker, Kaveh Memarzadeh
May 12, 2012·Archives of Toxicology·Robert LandsiedelFranz Oesch
Aug 1, 2013·International Journal of Nanomedicine·Kui LiuJinshun Zhao
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·David Julian McClements, Jiajia Rao
Oct 20, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jinshun Zhao, Vincent Castranova
Jun 1, 2014·International Journal of Environmental Research and Public Health·Alina Martirosyan, Yves-Jacques Schneider
Mar 9, 2010·Expert Opinion on Drug Delivery·Shaun D GittardRoger J Narayan
Aug 19, 2010·Expert Opinion on Drug Delivery·John W RasmussenDenise G Wingett
Jun 6, 2012·Expert Opinion on Drug Delivery·Sibel Ilbasmis-Tamer, Ismail Tuncer Degim
Sep 15, 2010·Expert Opinion on Drug Delivery·Nicolas Duceppe, Maryam Tabrizian
Sep 17, 2013·Journal of Pharmaceutical Sciences·Ajit S NarangMunir A Hussain
Dec 27, 2011·Neurotoxicology·William K BoyesRobert A Yokel
Nov 29, 2011·Journal of Hazardous Materials·Ruinan ZhangBing Yan
Dec 20, 2011·Toxicology and Applied Pharmacology·Sumit AroraKishore M Paknikar
Sep 20, 2011·Advanced Drug Delivery Reviews·Andreas Elsaesser, C Vyvyan Howard
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ae Jung Huh, Young Jik Kwon
Feb 5, 2010·Journal of Toxicology·A El-Ansary, S Al-Daihan
Feb 16, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Clara FernandesVandana Patravale
Mar 5, 2016·Environmental Science and Pollution Research International·Peter SchönGregor Luthe
Mar 20, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Lilian Calderón-GarcidueñasRichard L Doty
Nov 26, 2008·Regulatory Toxicology and Pharmacology : RTP·Hans BouwmeesterAdriënne J A M Sips
Mar 4, 2008·Advanced Drug Delivery Reviews·Karina R Vega-VillaNeal M Davies
Mar 11, 2016·Critical Reviews in Toxicology·Jia LiuLongquan Shao
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Gunnar Damgård NielsenSøren Thor Larsen
Apr 10, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert YokelRobert MacPhail
Mar 23, 2012·Journal of Applied Toxicology : JAT·Eun-Jung ParkJin Tae Hong
Jul 5, 2012·Journal of Applied Toxicology : JAT·Teresa L LeavensJim E Riviere
Jun 4, 2014·Journal of Applied Toxicology : JAT·Eun-Jung ParkDong-Wan Kim
Apr 27, 2011·IEEE Transactions on Nanobioscience·Federica SimonelliF Rossi
Apr 17, 2013·Particle and Fibre Toxicology·Hongbo ShiJinshun Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved