What does nisoldipine coat core (CC) add to current therapy that is clinically meaningful?

The American Journal of Cardiology
L H Opie

Abstract

Nisoldipine coat core (CC) is a long-acting dihydropyridine with good tolerability. Ambulatory blood pressure measurements in a large, South African multicenter trial show that it has an excellent trough:peak ratio, and that it reduces the early morning rise in blood pressure without any tachycardia. Nisoldipine CC is an effective antihypertensive agent in both black and nonblack South African ethnic groups. In another South African study, regression of left ventricular hypertrophy was achieved in black patients with severe diastolic hypertension. Safety issues are discussed against the background of the testing of this drug in postinfarct left ventricular dysfunction.

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·T GodfraindJ C Schoevaerts
Apr 1, 1993·American Heart Journal·M W GillmanR B D'Agostino
Jul 1, 1996·Journal of the American College of Cardiology·F H Messerli
Aug 1, 1996·European Heart Journal·C D FurbergB M Psaty
Nov 1, 1996·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P Hamet, L Gong

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