What drives quality of life in multiple sclerosis?

QJM : Monthly Journal of the Association of Physicians
L HemmettN Russell

Abstract

Extensive use of the EDSS measure of disease severity by clinicians, and the EQ-5D measure of quality of life by healthcare decision-makers, may not adequately reflect patient perceptions of the range and impact of their symptoms. To investigate the perceptions of MS patients in relation to specific symptoms and their general health-related quality of life. Questionnaire-based surveys. Two consecutive postal surveys were sent to people whose contact details were on the database of the MS Trust. The first was sent to all 8,614. Of 3,403 respondents, 1992 agreed to participate in a second survey. In the first survey (response rate 40%), 1993 respondents (88%) reported moderate or severe fatigue; of 266 receiving disease-modifying therapy, 109 (41%) felt it improved their fatigue. In the second (response rate 78%), mean EQ-5D Index and z scores on the related quality of life deficit were significantly lower for respondents with relapsing or progressive disease than for those with benign disease. In the former groups (total n=1178), over 90% reported problems with mobility and usual activities, and over 80% reported problems with pain. The lowest mean SF-36 scores were for role-physical, physical functioning and vitality, vitality ...Continue Reading

References

Apr 1, 1989·International Disability Studies·J Monks
Apr 1, 1988·Archives of Neurology·L B KruppL C Scheinberg
Nov 21, 1997·Medical Care·P Dolan
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G P RiceJ F Grenier
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J A FreemanA J Thompson
Jul 4, 2001·Disability and Rehabilitation·H L FordA Tennant
Nov 8, 2001·Disability and Rehabilitation·C R NichollT F Stephan
Jan 26, 2002·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A Solari, D Radice
Jun 25, 2002·The Journal of Nervous and Mental Disease·Stefan MerkelbachJochem Koenig
Oct 3, 2002·Multiple Sclerosis : Clinical and Laboratory Research·P VermerschT Stojkovic

❮ Previous
Next ❯

Citations

Jan 13, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Brian C HealyBonnie I Glanz
Jul 4, 2012·Clinical Neuropharmacology·Simone Di RezzeEnrico Millefiorini
Jan 24, 2014·International Journal of MS Care·Gael J YonnetJohn W Rose
Jul 22, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·H I KarpatkinB Siminovich-Blok
Dec 18, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ayse KuspinarNancy E Mayo
May 31, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M de Sèze, X Gamé
Oct 3, 2014·Journal of Comparative Effectiveness Research·Rafael ArroyoKerry L Dechant
May 14, 2005·Current Opinion in Neurology·Alan J Thompson
Jan 10, 2013·The International Journal of Neuroscience·C Oreja-GuevaraC Vila
Mar 18, 2010·International Review of Psychiatry·Odysseas KargiotisPanagiotis Papathanasopoulos
Oct 19, 2010·Journal of Medical Economics·Annette WundesCraig I Coleman
Dec 7, 2013·Expert Review of Neurotherapeutics·Ralf Gold
Apr 11, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Leonardo Koeser, Paul McCrone
Jun 4, 2011·Expert Opinion on Pharmacotherapy·Hillel Panitch, Angela Applebee
Dec 23, 2010·Disability and Rehabilitation·Jarmila SzilasiovaJitse P Van Dijk
Feb 21, 2009·Disability and Rehabilitation·A RombergL Poikkeus
Nov 18, 2009·Current Medical Research and Opinion·Matthew H Sutliff
Apr 1, 2011·Expert Review of Neurotherapeutics·Judith Haas
Feb 14, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·L Ramió-TorrentàA Saiz
Feb 13, 2013·Expert Review of Neurotherapeutics·Nicolas Collongues, Patrick Vermersch
Feb 10, 2016·Multiple Sclerosis and Related Disorders·K MilinisUNKNOWN TONiC study group
Jun 29, 2012·Revue neurologique·C Donzé, J De Sèze
Nov 4, 2015·Archives of Physical Medicine and Rehabilitation·Anna L KratzGeorge H Kraft
Apr 25, 2009·Physical Medicine and Rehabilitation Clinics of North America·Anjali Shah
Dec 22, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Elizabeth GoodwinAnne Spencer
Aug 19, 2007·Annals of Neurology·Richard A RudickUNKNOWN AFFIRM and SENTINEL Investigators
Apr 24, 2013·CNS Neuroscience & Therapeutics·Jana Lizrova PreiningerovaThomas Berger
Oct 25, 2013·Pain Practice : the Official Journal of World Institute of Pain·Timothy L VollmerSandra K Malcolm
Apr 1, 2016·Nature Reviews. Urology·Véronique PhéJalesh N Panicker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.