DOI: 10.1101/488254Dec 7, 2018Paper

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

BioRxiv : the Preprint Server for Biology
Alice R CarterAbbas Dehghan


Importance: Lower levels of education are causally related to higher cardiovascular risk, but the extent to which this is driven by modifiable risk factors also associated with education is unknown. Objective: To investigate the role of body mass index, systolic blood pressure and smoking in explaining the effect of education on risk of cardiovascular disease outcomes. Design: Multivariable regression analysis of observational data and Mendelian randomization (MR) analysis of genetic data. Setting: UK Biobank and international genome-wide association study consortia. Participants: Predominantly individuals of European ancestry. Main outcomes and measures: The effects of education (per 1-standard deviation increase, equivalent to 3.6 years) on coronary heart disease, cardiovascular disease (all subtypes), myocardial infarction and stroke risk (all measured in odds ratio, OR), and the degree to which this is mediated through body mass index, systolic blood pressure and smoking. Results: Each additional standard deviation of education associated with 15% lower risk of coronary heart disease (OR 0.87, 95% confidence interval [CI] 0.84 to 0.89) in observational analysis and 37% lower risk (OR 0.63, 95% CI 0.60 to 0.67) in Mendelian ...Continue Reading

Related Concepts

Blood Pressure
Cardiovascular Diseases
Coronary Heart Disease
Myocardial Infarction
Regression Analysis
Cerebrovascular Accident
Subtype (Attribute)
Systolic Pressure
Body Mass Index

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