What factors are associated with the poor prognosis of anal adenocarcinoma compared with low-lying rectal adenocarcinoma based on a population analysis: A propensity score matching study

PloS One
Qinghua WangJinlin Du

Abstract

Anal adenocarcinoma (AA) represents a rare condition, and little is known about the predictive factors of the outcomes or the optimal TNM staging system for curable AA. Using population-based data, we preliminarily sought to determine the prognostic factors and evaluate the existing T and N staging criteria of AA. We analyzed the Surveillance, Epidemiology, and End Results 18 database to identify patients 20-80 years old who were diagnosed with AA or rectal adenocarcinoma (RA) and underwent abdominal perineal resection between 2004 and 2012. The difference between Kaplan-Meier survival curves was estimated by a log-rank test. A Cox proportional hazard regression model was used to adjust the effects of other covariates on survival in the propensity score-matched cohort, including age, gender, race, marital status, histology, grade of differentiation, tumor size, number of positive lymph nodes, radiotherapy, and chemotherapy. Compared to patients with RA, patients with AA had a worse CSS after controlling for other covariates (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.25-3.07; P<0.01). For AA, the increasing tumor size (2-5 cm: HR, 0.62; 95% CI, 0.29-1.32; P>0.05; >5 cm: HR, 1.01; 95% CI, 0.49-2.07; P>0.05) had no ...Continue Reading

References

Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Yazid BelkacémiUNKNOWN Rare Cancer Network
Oct 27, 2006·Annals of Surgical Oncology·Eelco de BreeFrans A N Zoetmulder
Feb 26, 2009·Annals of Surgical Oncology·Nicole KounalakisLily L Lai
Dec 31, 2009·Cancer·Prajnan DasChristopher H Crane
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 17, 2011·International Journal of Radiation Oncology, Biology, Physics·Cécile OrtholanDidier Cowen
Jul 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S AnwarD Sebag-Montefiore
May 14, 2014·Diseases of the Colon and Rectum·Sanne E BlindeJoost J Nuyttens
Aug 19, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alexis LépinoyJean-F Bosset
Aug 25, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Vishwas D PaiAvanish P Saklani
Aug 27, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christoph HenkenberensHans Christiansen
Apr 9, 2016·Annals of Medicine and Surgery·Dedrick Kok-Hong ChanKer-Kan Tan
Aug 17, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dedrick Kok Hong Chan, Ker-Kan Tan
Nov 29, 2016·Journal of Surgical Oncology·Jianfei FuJinlin Du

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SE
STATA
SEER Stat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Fatma Oz AtalayHakan Vuruskan
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Michelle Kang KimJuan P Wisnivesky
© 2021 Meta ULC. All rights reserved