What fires prometheus? The link between inflammation and regeneration following chronic liver injury

The International Journal of Biochemistry & Cell Biology
Cornelia S Viebahn, George Yeoh

Abstract

Liver progenitor cells (LPCs) play a major role in the regeneration process after chronic liver damage, giving rise to hepatocytes and cholangiocytes. Thus, they provide a cell-based therapeutic alternative to organ transplant, the current treatment of choice for end-stage liver disease. In recent years, much attention has focused on unravelling the cytokines and growth factors that underlie this response. Liver regeneration following acute damage is achieved by proliferation of mature hepatocytes; yet similar cytokines, most related to the inflammatory process, are implicated in both acute and chronic liver regeneration. Thus, many recent studies represent attempts to identify LPC-specific factors. This review summarises our current understanding of LPC biology with a particular focus on the liver inflammatory response being associated with the induction of LPCs in the liver. We will describe: (i) the pathways of liver regeneration following acute and chronic damage; (ii) the similarities and differences between the two pathways; (iii) the liver inflammatory environment; (iv) the unique features of liver immunology as well as (v) the interactions between liver immune cells and LPCs. Combining data from studies on the LPC-drive...Continue Reading

References

Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MitakaH C Pitot
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E Mead, N Fausto
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M SteffanA Kirn
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E M WebberN Fausto
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B E PetersenG K Michalopoulos
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P NagyS S Thorgeirsson
Aug 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I KirmanO H Nielsen
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T KinoshitaA Miyajima
Jul 28, 1999·International Immunology·P BertolinoC Rabourdin-Combe
Oct 9, 1999·The American Journal of Pathology·H C BisgaardS S Thorgeirsson
Dec 22, 1999·European Journal of Immunology·F GalbiatiL Adorini
Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RosenbergS Sell
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
Aug 11, 2000·Journal of Gastroenterology and Hepatology·H Ishii, H Saito
Apr 6, 2001·The American Journal of Pathology·S PakuS S Thorgeirsson
Aug 3, 2001·Blood Cells, Molecules & Diseases·B E Petersen
Nov 26, 2002·The Journal of Biological Chemistry·Christopher J NelsenJeffrey H Albrecht
Dec 7, 2002·Seminars in Cell & Developmental Biology·Raza MalikHumphrey Hodgson
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bryon E PetersenEdward W Scott
Sep 26, 2003·The American Journal of Pathology·Tania RoskamsAnna Mae Diehl
Jan 15, 2004·Seminars in Liver Disease·Malcolm R Alison
Jan 15, 2004·Seminars in Liver Disease·Tania A RoskamsValeer J Desmet
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koji NakamuraAtsushi Miyajima
May 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hélène Strick-MarchandMary C Weiss
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tania A RoskamsA Brian West
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Sep 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shoshiro OeSnorri S Thorgeirsson
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Rebecca Taub
Nov 24, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Vance B MatthewsGeorge C T Yeoh
Dec 8, 2004·The American Journal of Pathology·Philippe MavierElie Serge Zafrani
Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barbara AkhurstGeorge C Yeoh
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George K MichalopoulosWilliam C Bowen
Mar 31, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John T BroolingNelson Fausto

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Citations

Apr 23, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carmen HerenciaJuan R Muñoz-Castañeda
May 18, 2013·Frontiers of Medicine·Beicheng Sun, Michael Karin
Sep 29, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marie-Noële ChobertArthur Brouillet
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Janina E E Tirnitz-ParkerGrant A Ramm
Jul 8, 2010·Journal of Hepato-biliary-pancreatic Sciences·Masato Fujiyoshi, Michitaka Ozaki
Jul 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Caryn L ElsegoodGeorge C T Yeoh
Apr 23, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Aezam KatoonizadehReza Malekzadeh
May 24, 2020·International Journal of Molecular Sciences·Fengming XuUta Dahmen
Nov 18, 2016·Frontiers in Cell and Developmental Biology·Stella MichaelKaterina Strati
Sep 6, 2019·Stem Cells International·Neil Andrewartha, George Yeoh
May 21, 2019·The American Journal of Pathology·Laure-Alix ClerbauxIsabelle A Leclercq

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