What generates flux of tubulin in kinetochore microtubules?

Protoplasma
Arthur ForerT Spurck

Abstract

We discuss models for production of tubulin flux in kinetochore microtubules. Current models concentrate solely on microtubules and their associated motors and enzymes. For example, in some models the driving force for flux is enzymes at the poles and the kinetochores; in others the driving force is motor molecules that are associated with a stationary spindle matrix. We present a different viewpoint, that microtubules are propelled poleward by forces arising from the spindle matrix, that the forces on the microtubules "activate" polymerising and depolymerising enzymes at kinetochores and poles, that matrix forces utilise actin, myosin, and microtubule motors, and that the matrix itself may not necessarily be static.

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Citations

Mar 4, 2009·Protoplasma·Jeremy Pickett-Heaps, Art Forer
Jul 8, 2009·The Journal of Cell Biology·Irina MatosHelder Maiato
Apr 10, 2013·European Journal of Cell Biology·Rozhan SheykhaniArthur Forer
May 4, 2010·European Journal of Cell Biology·Arthur Forer, Jeremy Pickett-Heaps
Jul 14, 2009·European Journal of Cell Biology·Péter VilmosMiklós Erdélyi
Nov 6, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hongying QiJørgen Johansen
Jul 28, 2009·Developmental Biology·Yun DingJørgen Johansen
Jul 19, 2018·Histochemistry and Cell Biology·Csaba BajuszPéter Vilmos

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