What goes up, can come down: Novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals

Brain Research
Colleen A HanlonMark S George

Abstract

Vulnerability to drug related cues is one of the leading causes for continued use and relapse among substance dependent individuals. Using drugs in the face of cues may be associated with dysfunction in at least two frontal-striatal neural circuits: (1) elevated activity in medial and ventral areas that govern limbic arousal (including the medial prefrontal cortex (MPFC) and ventral striatum) or (2) depressed activity in dorsal and lateral areas that govern cognitive control (including the dorsolateral prefrontal cortex (DLPFC) and dorsal striatum). Transcranial magnetic stimulation (TMS) is emerging as a promising new tool for the attenuation of craving among multiple substance dependent populations. To date however, nearly all repetitive TMS studies in addiction have focused on amplifying activity in frontal-striatal circuits that govern cognitive control. This manuscript reviews recent work using TMS as a tool to decrease craving for multiple substances and provides a theoretical model for how clinical researchers might approach target and frequency selection for TMS of addiction. To buttress this model, preliminary data from a single-blind, sham-controlled, crossover study of 11 cocaine-dependent individuals is also present...Continue Reading

Associated Clinical Trials

References

Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Mar 11, 1999·Biological Psychiatry·D E BohningM S George
Jan 4, 2003·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Gopakumar P. Panikkar
Aug 21, 2003·The Journal of Clinical Psychiatry·Peter EichhammerGöran Hajak
Jan 20, 2004·Journal of Chemical Neuroanatomy·Suzanne N Haber
Mar 30, 2004·Annals of Neurology·Stéphane LehéricyDae-Shik Kim
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
May 5, 2005·The European Journal of Neuroscience·A KüblerH Garavan
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Aug 8, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paul B FitzgeraldZafiris J Daskalakis
Jan 27, 2007·Science·Nasir H NaqviAntoine Bechara
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
May 15, 2007·The American Journal of Drug and Alcohol Abuse·James PolingMehmet Sofuoglu
Jul 10, 2008·The American Journal on Addictions·Ernestina PolitiEnrico Smeraldi
Sep 4, 2009·Drug and Alcohol Dependence·Sudie E BackKathleen T Brady
Nov 17, 2009·Neuroscience and Biobehavioral Reviews·Jodie Feil, Abraham Zangen
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Scott L Rauch
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Garret D Stuber
Feb 16, 2010·Psychiatry Research·F Gerard MoellerPonnada A Narayana
Oct 1, 2008·Brain Stimulation·Vincenzo Di LazzaroRoger N Lemon
Jan 1, 2009·Brain Stimulation·Ying-Zu HuangYoshikazu Ugawa
Jul 17, 2010·Brain Stimulation·Janna Marie HoogendamVincenzo Di Lazzaro
Mar 19, 2011·Pharmacological Reviews·Sarah C Rogan, Bryan L Roth
Jul 28, 2011·Current Psychiatry Reports·Rajita Sinha
Sep 16, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jacqueline HöppnerJohannes Thome
Sep 21, 2011·Addiction Biology·Zhen Fang Huang CaoZoltán Sarnyai
Dec 14, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan M Ferguson, John F Neumaier
Dec 27, 2011·Biological Psychiatry·Garret D StuberAntonello Bonci
Dec 28, 2011·International Review of Psychiatry·Mera S BarrZafiris J Daskalakis
Mar 7, 2012·Drug and Alcohol Dependence·Laura Moreno-LópezAntonio Verdejo-García
Jul 20, 2012·Brain Stimulation·Victoria C WingTony P George
Jul 25, 2012·Addiction Biology·Michael T StefanikRyan T LaLumiere
Oct 4, 2012·Brain Research·Elizabeth E Steinberg, Patricia H Janak
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kyle S SmithAnn M Graybiel
Jan 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph J TaylorMark S George
Feb 21, 2013·Brain Research·Gary Aston-Jones, Karl Deisseroth
May 28, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S C HerremansC Baeken

❮ Previous
Next ❯

Citations

Feb 26, 2016·Frontiers in Neuroscience·Katharine A DunlopJonathan Downar
Feb 6, 2016·Annals of the New York Academy of Sciences·Katharine DunlopJonathan Downar
Jul 5, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colleen A HanlonMark S George
Jun 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael C Salling, Diana Martinez
Oct 28, 2016·European Eating Disorders Review : the Journal of the Eating Disorders Association·Aurelia GaySebastien Guillaume
Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A GayC Massoubre
Aug 15, 2017·The American Journal of Drug and Alcohol Abuse·Gregory L SahlemAimee L McRae-Clark
Sep 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M HolsenL E Stoeckel
Jul 26, 2018·The European Journal of Neuroscience·Maria M DiehlDavid V Smith
May 18, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Graziella Madeo, Antonello Bonci
Jul 3, 2020·Journal of Psychiatry and Brain Science·Stephan F TaylorLuis Hernandez-Garcia
Jul 29, 2020·Journal of Clinical Medicine·Philibert DuriezSébastien Guillaume
Jan 14, 2017·Brain : a Journal of Neurology·Primavera A Spagnolo, David Goldman
Feb 20, 2018·The American Journal on Addictions·Alexandria S ColesTony P George
Jun 6, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rodrigo C MarquesAmaury Cantilino
Oct 9, 2019·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Antoine BecharaJeffrey S Stein
Mar 23, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sarah CooperMichelle S Mazei-Robison
Jun 28, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Raoul DieterichTanja Endrass
Mar 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tonisha Kearney-Ramos, Margaret Haney
Nov 10, 2017·Drug and Alcohol Dependence·Christine E ShefferAntonio Mantovani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.