What happened to enterovirus D68 infections in 2015?

Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada
D HarrisJeffrey M Pernica

Abstract

Enterovirus-D68 (EV-D68) was observed in association with severe respiratory disease in children in North America and around the world in the fall of 2014. To compare fall 2014 detection rates with fall 2015 detection rates of EV-D68 in nasopharyngeal swab (NPS) samples collected for routine clinical care from a large regional laboratory in south-central Ontario. Consecutive NPS samples submitted from inpatients and outpatients in Hamilton, Niagara Region and Burlington to the Regional Virology Laboratory were tested with multiplex polymerase chain reaction (PCR) for rhinovirus/enterovirus (as a single target) and for other common respiratory viruses. All NPS samples positive for rhinovirus/enterovirus were reflexed to a lab-developed single target PCR for EV-D68 detection. In 2014, between August 1 and October 31, 566 of 1,497 (38%, 95%CI 35-40%) NPS samples were rhino/enterovirus positive, of which 177 (31%, 95%CI 27-35%) were confirmed as EV-D68. In 2015, between August 1 and October 31, 472 of 1,630 (29%, 95%CI 27-31%) NPS samples were rhino/enterovirus positive, of which none (0%, upper limit 97.5%CI 0.8%) were confirmed to be EV-D68. Based on testing results, there appears to be much less circulating EV-D68 in south centr...Continue Reading

References

Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Neil W JohnstonMalcolm R Sears
Oct 23, 2010·Lancet Neurology·Mong How OoiTom Solomon
Feb 28, 2014·The New England Journal of Medicine·Fengcai ZhuNan Wang
Feb 28, 2014·The New England Journal of Medicine·Rongcheng LiQihan Li
Sep 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Randy PoelmanUNKNOWN ESCV-ECDC EV-D68 study group
Oct 16, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Dominik MertzMarek Smieja
Feb 20, 2015·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·T F BoothA McDermid
Feb 20, 2015·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·J J EdwinT Wong

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