What has inflammation to do with traumatic brain injury?

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
David Cederberg, Peter Siesjö

Abstract

Inflammation is an stereotypical response to tissue damage and has been extensively documented in experimental and clinical traumatic brain injury (TBI), including children. The initiation and orchestration of inflammation in TBI, as in other tissues, is complex and multifactorial encompassing pro- and anti-inflammatory cytokines, chemokines, adhesion molecules, complement factors, reactive oxygen and nitrogen species, and other undefined factors. It is evident that inflammation can have both beneficial and detrimental effects in TBI, but the mechanisms underlying this dichotomy are mostly unknown. Modification of the inflammatory response may be neuroprotective. Monitoring inflammation is now possible with techniques such as microdialysis; however, the prognostic value of measuring inflammatory mediators in TBI is still unclear with conflicting reports. Except for corticosteroids, no anti-inflammatory agents have been tested in TBI, and the negative results with these may have been flawed by their multiple side effects. Clinical trials with anti-inflammatory agents that target multiple or central and downstream pathways are warranted in adult and pediatric TBI. This review examines the mechanisms of inflammation after TBI, mon...Continue Reading

References

Jan 1, 1986·Journal of Neurosurgery·N M DeardenM M Cameron
Mar 1, 1997·Molecular Psychiatry·M C Morganti-KossmanT Kossmann
May 1, 1997·British Journal of Anaesthesia·E G McKeatingL Mascia
May 21, 1998·Brain Research·E H HausmannR M Klein
Sep 5, 1998·Brain Research. Brain Research Reviews·P F StahelT Kossmann
May 6, 1999·Intensive Care Medicine·P KalabalikisJ Papadatos
Apr 25, 2000·Neuroscience Letters·K FassbenderM Hennerici
May 16, 2000·Critical Care Medicine·M J WhalenP D Adelson
Jan 10, 2002·Journal of Neurotrauma·B M BellanderM Svensson
Feb 8, 2002·Molecular Neurobiology·P M LenzlingerT K McIntosh
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaopeng ZhangRobert S B Clark
Dec 3, 2003·Brain : a Journal of Neurology·Craig D WinterMartin K Church
Jun 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yi Long MaKelly L Drew
Apr 26, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zerong YouMichael J Whalen
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Apr 17, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arieh MoussaieffEsther Shohami
May 2, 2008·Journal of Neurosurgery·Roberto StefiniNicola Latronico
Jul 8, 2008·Progress in Neurobiology·Zachary M WeilRandy J Nelson
Jan 10, 2009·Annual Review of Immunology·Cedric AuffrayFrederic Geissmann
Apr 28, 2009·Frontiers in Neuroendocrinology·Luis M Garcia-Segura, Jacques Balthazart

❮ Previous
Next ❯

Citations

Oct 8, 2011·Brain Imaging and Behavior·Jenifer JuranekLinda Ewing-Cobbs
Jan 14, 2011·Journal of Clinical and Experimental Neuropsychology·Kenny LinUNKNOWN CHARTER group
Oct 20, 2012·Journal of Neurotrauma·Linda PapaRachel P Berger
Oct 16, 2012·Journal of Neuroinflammation·Mahasweta DasShyam S Mohapatra
Dec 1, 2012·Stem Cells Translational Medicine·Jordane MalaterreRobert G Ramsay
Oct 23, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yang-Chun HuChun-Hua Hang
Sep 14, 2013·Trends in Cell Biology·Nikos KyritsisMichael Brand
Apr 26, 2014·Journal of Neuroinflammation·L Christine TurtzoJoseph A Frank
Aug 19, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nicole A Northrop, Bryan K Yamamoto
Dec 14, 2011·Topics in Magnetic Resonance Imaging : TMRI·Elan J GrossmanRoland Bammer
Jan 15, 2013·Molecular Neurobiology·Menaka C ThounaojamAnirban Basu
Dec 10, 2015·Journal of Affective Disorders·Ying-Chen ChiYing-Yeh Chen
Sep 26, 2013·Brain Injury : [BI]·Nino Muradashvili, David Lominadze
Mar 11, 2015·British Journal of Pharmacology·Ila P KarvePeter J Crack
Jan 28, 2016·Neuroscience and Biobehavioral Reviews·Zachary M WeilKate Karelina
Apr 30, 2013·The Journal of Surgical Research·Sung H YangAlex B Lentsch
Sep 24, 2011·Progress in Neurobiology·Adel HelmyPeter J Hutchinson
Nov 4, 2015·Frontiers in Behavioral Neuroscience·Vanessa M DoulamesThomas B Shea
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrea S VincentAlison Cernich
Aug 1, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kristina CieslakDolores Malaspina
Aug 21, 2012·American Journal of Obstetrics and Gynecology·Alan Leviton
Apr 17, 2012·Neuroscience Letters·Jonathan RasouliDiana Casper
Aug 2, 2014·Journal of Neuroimmunology·Stine MenclChristoph Kleinschnitz
Jun 16, 2012·Mediators of Inflammation·Sarah Claire Hellewell, Maria Cristina Morganti-Kossmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Jenna M Ziebell, M C Morganti-Kossmann
Brain Research. Brain Research Reviews
Oliver I SchmidtPhilip F Stahel
Current Opinion in Critical Care
M C Morganti-KossmannT Kossmann
© 2022 Meta ULC. All rights reserved