What Have In Vitro Co-Culture Models Taught Us about the Contribution of Epithelial-Mesenchymal Interactions to Airway Inflammation and Remodeling in Asthma?

Cells
Emmanuel T OseiTillie-Louise Hackett

Abstract

As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been associated with airway inflammation and remodeling, which has led to the hypothesis that aberrant activation of the asthmatic EMTU may lead to disease pathogenesis. Monoculture studies have aided in the understanding of the altered phenotype of airway epithelial and mesenchymal cells and their contribution to the pathogenesis of asthma. However, 3-dimensional (3D) co-culture models are needed to enable the study of epithelial-mesenchymal crosstalk in the setting of the in vivo environment. In this review, we summarize studies using 3D co-culture models to assess how defective epithelial-mesenchymal communication contributes to chronic airway inflammation and remodeling within the asthmatic EMTU.

References

Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·A E RedingtonP H Howarth
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H K MakkerS T Holgate
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·M J EvansC G Plopper
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H Y Zhang, S H Phan
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·S T HolgateJ L Lordan
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·Y MorishimaK Sekizawa
Apr 18, 2001·International Archives of Allergy and Immunology·S T HolgateD E Davies
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A SwartzJ M Drazen
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·P R JohnsonJ L Black
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Jeffrey J Atkinson, Robert M Senior
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Sarah M PuddicombeDonna E Davies
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Daniel J TschumperlinJeffrey M Drazen
Feb 18, 2003·The Journal of Allergy and Clinical Immunology·Donna E DaviesStephen T Holgate
Mar 12, 2003·Chest·Paul M O'Byrne, Mark D Inman
Oct 30, 2003·The European Respiratory Journal. Supplement·S T HolgateP Howarth
Feb 11, 2004·Current Allergy and Asthma Reports·Peter R A Johnson, Janette K Burgess
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniPeter K Jeffery
Feb 8, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P PohunekW R Roche
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Carmela PepeQutayba Hamid
Feb 18, 2006·European Journal of Pharmacology·Laurent ReberNelly Frossard
Aug 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·H Garrett R ThompsonSteven C George
Oct 27, 2006·Proceedings of the American Thoracic Society·Edith PuchelleChristelle Coraux
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Ruth H GreenPeter Bradding
Jan 24, 2007·Physiological Reviews·Kendra J GreenleeFarrah Kheradmand
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tao LuGeorge R Stark
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Lance CohenUNKNOWN NHLBI Severe Asthma Research Program (SARP)
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Nov 5, 2008·The Journal of Clinical Investigation·Peter J Barnes
Dec 17, 2008·The Journal of Allergy and Clinical Immunology·Ruth SaundersChristopher E Brightling
Jan 20, 2009·American Journal of Respiratory Cell and Molecular Biology·Nikita K MalaviaSteven C George
Dec 5, 2009·Circulation Research·Colby A SoudersTroy A Baudino
Dec 17, 2009·Proceedings of the American Thoracic Society·Donna E Davies
Apr 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lynn M Crosby, Christopher M Waters
Aug 3, 2010·Acta Biotheoretica·Liesbet GerisRichard C Schugart
Aug 12, 2010·Disease Models & Mechanisms·Jason R RockBrigid L M Hogan
May 29, 2012·Pulmonary Pharmacology & Therapeutics·Yuxiu C XiaRachel L Clifford
Jul 18, 2012·The Journal of Experimental Medicine·Monique A M WillartHamida Hammad
Oct 1, 2013·American Journal of Respiratory Cell and Molecular Biology·Luigino CalzettaAugusto Orlandi
May 31, 2014·The Journal of Allergy and Clinical Immunology·Stephen R ReevesJason S Debley
Sep 27, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T-Y LinQ Hamid
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria R BonsignoreMark Gjomarkaj

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Citations

Jul 14, 2021·Advanced Drug Delivery Reviews·Mohammed Ali SeloCarsten Ehrhardt
Aug 28, 2021·Cells·Tillie Louise Hackett, Emmanuel Twumasi Osei

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Methods Mentioned

BETA
biopsies
lavage
PAECs
bioprinting

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