Abstract
Mast cells (MC) have been implicated in the activation of vascular endothelial cells, capillary leak formation, transmigration of white blood cells, and translocation of fibrinogen (and other plasma molecules) into the tissues, with consecutive edema formation. However, the mechanisms of repair that lead to tissue reconstitution after MC activation and edema formation have not been defined so far. In the present article, the possible contribution of MC to repair, in particular fibrinolysis, is discussed. Thus, accumulating evidence exists that human MC express and release the tissue-type plasminogen activator (tPA) in a constitutive manner. MC also express the urokinase receptor (uPAR) and heparin. Most importantly, however, MC lack plasminogen activator inhibitors (PAI-1, PAI-2, PAI-3). In line with this 'pro-fibrinolytic' profile of antigens, MC supernatants induce plasminogen-to-plasmin conversion and fibrin clot lysis in vitro. The c-kit ligand SCF upregulates uPAR expression, and the release of tPA from MC. These observations point to an important role of MC in endogenous fibrinolysis, a hitherto unrecognized (repair) function of this cell.
Citations
May 29, 2002·Thrombosis Research·Hans C Bankl, Peter Valent
Dec 12, 2001·Neuroscience·T CaoS D Brain
Feb 28, 2002·Trends in Immunology·Frédéric FégerMichel Arock
Jan 19, 2013·Cell Death & Disease·K WoidackiA C Zenclussen
Sep 5, 2001·Neuropathology and Applied Neurobiology·P G Krüger
Aug 9, 2003·Critical Care Medicine·Rhonda S FishelAdrian Barbul
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Isabel PrietoJaime Arias
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·Johann WojtaPeter Valent
Oct 30, 2004·Leukemia & Lymphoma·Frank NoackHans-Peter Horny
Jul 5, 2011·Toxicology Letters·Anil K JainRajesh Agarwal
Jul 13, 2001·American Journal of Clinical Pathology·H C BanklP Valent
Aug 16, 2003·Clinical Cardiology·Krzysztof J FilipiakAndrzej Czlonkowski
May 15, 2007·Immunological Reviews·Stephan C Bischoff, Sigrid Krämer
Jul 6, 2010·European Journal of Clinical Investigation·Peter Valent
Dec 18, 2013·Biomaterials·Yi-Ting TsaiLiping Tang
Aug 28, 2004·Expert Opinion on Pharmacotherapy·Mark B Abelson
Dec 12, 2001·Medical Hypotheses·M A AllerJ Arias
Jan 25, 2003·Coronary Artery Disease·Sinkiewicz Władysław
Feb 15, 2002·Veterinary Dermatology·C Noli, A Miolo
May 20, 1999·American Journal of Hematology·F WimazalP Valent
Apr 18, 2002·Archives of Pathology & Laboratory Medicine·Ruliang XuJonathan Melamed
Feb 24, 1999·Human Pathology·H C BanklP Valent