What have we learned about how to prevent and treat antibody-mediated rejection in kidney transplantation?

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Peter W Nickerson

Abstract

Antibody-mediated rejection (ABMR) in kidney transplantation is a major cause of late graft loss, and despite all efforts to date the "standard of care" remains plasmapheresis, IVIg, and steroids, which itself is based on low quality evidence. This review focuses on the risk factors leading to memory and de novo donor-specific antibody (DSA)-associated ABMR, the optimal prevention strategies for ABMR, and advances in  adjunctive and emerging therapies for ABMR. Because new agents require regulatory approval via a Phase 3 randomized control trial (RCT), an overview of progress in innovative trial design for ABMR is provided. Finally, based on the insights gained in the biology of ABMR, current knowledge gaps are identified for future research that could significantly affect our understanding of how to optimally treat ABMR.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S SuematsuT Kishimoto
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Apr 3, 1969·The New England Journal of Medicine·R Patel, P I Terasaki
Dec 1, 1996·Frontiers in Bioscience : a Journal and Virtual Library·E T KellerW B Ershler
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lorraine C RacusenKiril Trpkov
Feb 11, 2005·The New England Journal of Medicine·Duska DragunGerd Wallukat
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina RochmanS Z Ben-Sasson
Aug 31, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A BrayH M Gebel
Feb 7, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T FahimH Regele
Mar 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezJ J Weening
Feb 4, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B SisA Zeevi
Feb 4, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M GloorM D Stegall
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F VincentiC P Larsen
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DurrbachJ Grinyó
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L G HidalgoP F Halloran
Nov 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J SellarésP F Halloran
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L LiefeldtK Budde
Feb 18, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P ArchdeaconJ Meyer
Mar 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Nov 20, 2012·Journal of the American Society of Nephrology : JASN·Sumit MohanJai Radhakrishnan
Feb 6, 2013·Transplantation·Matthew J EverlyPaul I Terasaki
Feb 26, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H CardinalM J Hébert
Sep 27, 2013·The New England Journal of Medicine·Alexandre LoupyXavier Jouven
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Dec 21, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E J KimS J Knechtle
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasUNKNOWN Banff meeting report writing committee
Apr 26, 2014·Cancer Immunology Research·Toshio Tanaka, Tadamitsu Kishimoto
Jun 1, 2014·Transplantation·Raymond L HeilmanKunam Sudhakar Reddy
Jun 11, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B J OrandiD L Segev
Dec 19, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Sapir-PichhadzeS J Kim
Jan 4, 2015·Journal of the American Society of Nephrology : JASN·Alexandre LoupyCarmen Lefaucheur
May 1, 2015·Journal of the American Society of Nephrology : JASN·Donald E HricikUNKNOWN Clinical Trials in Organ Transplantation-09 Consortium
Jun 23, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Jun 23, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Sep 30, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianjun ChenAnita S Chong
Dec 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D VigliettiC Lefaucheur
Jan 6, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D StegallR B Mannon

❮ Previous
Next ❯

Citations

Jan 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Suk Kyun HongKyung-Suk Suh
Apr 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Christian BachMichael S Wiesener
Aug 19, 2021·The New England Journal of Medicine·Sundaram HariharanGabriel Danovitch
Sep 2, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Susumu Eguchi
Sep 11, 2021·HLA : Immune Response Genetics·Xirui LiChangxi Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Pharmacology
Min Young Kim, Daniel C Brennan
Current Opinion in Nephrology and Hypertension
Clément GossetDenis Glotz
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P F HalloranJ Reeve
© 2022 Meta ULC. All rights reserved