What have we learned from the IL28 receptor knockout mouse?

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Markus MordsteinPeter Staeheli

Abstract

The recently discovered type III interferons (IFNs), also known as IFN-lambda, are part of the early innate immune response against viral infections. The IFN-lambda system closely resembles the type I IFN (IFN-alpha/beta) system in terms of expression after virus infection as well as intracellular signaling and activation of antiviral host factors in susceptible cells. However, in contrast to type I IFN, which signals through a universally expressed cell surface receptor, IFN-lambda uses a distinct receptor complex (IL28R) for signaling, which is expressed on a limited range of cell types. Until recently both the contribution of type III IFN to antiviral resistance as well as the exact nature of IL28R-expressing cells in vivo remained elusive. In this review we discuss data obtained from the experiments with IL28Ralpha(0/0) mice that demonstrated the role of IFN-lambda in viral defense in vivo. We further discuss the experiments that identified the cell types in various organs that express functional IFN-lambda receptors.

References

Oct 1, 1988·Molecular and Cellular Biology·P StaeheliO Haller
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Dec 17, 2002·Nature Immunology·Sergei V KotenkoRaymond P Donnelly
Feb 26, 2005·Journal of Virology·Michael D RobekFrancis V Chisari
May 26, 2005·The Journal of General Virology·Nathan W BartlettGeoffrey L Smith
Jul 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Aug 15, 2006·Nature Medicine·Marco ContoliSebastian L Johnston
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sean E DoyleKevin M Klucher
Dec 8, 2006·Journal of Virology·Iris KoernerPeter Staeheli
Jan 6, 2007·The Journal of Biological Chemistry·Kazuhide OnoguchiTakashi Fujita
Mar 16, 2007·Genes and Immunity·W J JordanG Gallagher
Mar 21, 2007·Biochimie·Gilles Uzé, Danièle Monneron
Apr 7, 2007·The Journal of General Virology·Georg KochsPeter Staeheli
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiaying HuangSergei V Kotenko
Jul 27, 2007·Journal of Virology·Terrence M TumpeyPeter Staeheli
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina AnkSøren R Paludan
Jul 22, 2009·Revue Scientifique Et Technique·O HallerG Kochs
Sep 15, 2009·Nature Genetics·Vijayaprakash SuppiahJacob George

❮ Previous
Next ❯

Citations

Aug 18, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Raymond P Donnelly, Sergei V Kotenko
May 29, 2012·Journal of Leukocyte Biology·Suwan SinhaDorothy Yuan
Mar 19, 2013·Viruses·Frédéric SorgeloosThomas Michiels
Jul 23, 2015·Immunity·Helen M LazearMichael S Diamond
Mar 26, 2011·Virology·Fayna Díaz-San SegundoTeresa de los Santos
May 9, 2014·Frontiers in Cellular and Infection Microbiology·Olivier DussurgetPascale Cossart
Nov 15, 2014·PloS One·Sebastian ScheerMarinus C Lamers
Oct 3, 2012·Journal of Leukocyte Biology·J Eckl-Dorna
Jun 18, 2017·Arthritis Research & Therapy·Vilija OkeElisabet Svenungsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Raymond P Donnelly, Sergei V Kotenko
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Håkan C Steen, Ana M Gamero
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Kerstin WolkRobert Sabat
© 2021 Meta ULC. All rights reserved