What have we learnt about the management of diabetic macular edema in the antivascular endothelial growth factor and corticosteroid era?

Current Opinion in Ophthalmology
Aniruddha AgarwalQuan D Nguyen

Abstract

To summarize the outcomes of the use of antivascular endothelial growth factor (anti-VEGF) agents and corticosteroids on the treatment paradigm for diabetic macular edema (DME). Favorable efficacy data along with acceptable long-term safety results of anti-VEGF agents have made them the standard first-line therapy in the management of DME. Level I evidence from large, multicenter clinical trials has established the beneficial role of anti-VEGF agents and intravitreal steroids. In addition, the role of anti-VEGF agents in the treatment of diabetic retinopathy has also been recently recognized. However, concerns such as suboptimal response, VEGF resistance, and long-term effects on retinal layers and vasculature have also been highlighted recently. The use of anti-VEGF agents and corticosteroids has revolutionized the management of DME. Despite the advantages including ease of administration, low incidence of adverse events, and concomitant improvement in retinopathy status, limitations of this therapeutic approach have been recognized. The current review will focus on the lessons learnt in the management of DME in the anti-VEGF and steroid era.

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Citations

Nov 3, 2015·Expert Opinion on Pharmacotherapy·Aniruddha AgarwalQuan Dong Nguyen
Oct 23, 2015·Journal of Proteome Research·Sirpa LoukovaaraMarkku Varjosalo
Aug 22, 2015·Current Diabetes Reports·Aniruddha AgarwalQuan Dong Nguyen
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Jun 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Zaheer AliLasse Dahl Jensen

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