What If Low Back Pain Is the Most Prevalent Parkinsonism in the World?

Frontiers in Neurology
Jesse V JacobsF B Horak

Abstract

Low back pain (LBP) has a point prevalence of nearly 10% and ranks highest in global disease burden for years lived with disability; Parkinson's disease (PD) ranks in the top 100 most disabling health conditions for years lost and years lived with disability (1). Recent evidence suggests that people with chronic, recurrent LBP exhibit many postural impairments reminiscent of a neurological postural disorder such as PD. We compare and contrast postural impairments associated with LBP and PD in order to inform treatment strategies for both conditions. The literature suggests that both LBP and PD associate with impaired proprioceptive function, sensory orientation during standing balance, anticipatory postural adjustments, automatic postural responses, and striatal-cortical function. Although postural impairments are similar in nature for LBP and PD, the postural impairments with LBP appear more specific to the trunk than for PD. Likewise, although both health conditions associate with altered striatal-cortical function, the nature of the altered neural structure or function differ for PD and LBP. Due to the high prevalence of LBP associated with PD, focused treatment of LBP in people with PD may render benefit to their postural i...Continue Reading

References

Jan 1, 1992·Progress in Neurobiology·J Massion
Jul 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·T KlockgetherJ Dichgans
Jun 1, 1997·Annals of Neurology·M DemirciM Hallett
Apr 7, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R K ChongJ Kaye
Sep 17, 1999·Archives of Physical Medicine and Rehabilitation·P W Hodges, C A Richardson
Aug 29, 2003·Journal of Neurophysiology·Diana DimitrovaJohn G Nutt
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Susanne M Morton, Amy J Bastian
Feb 1, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A BartolićS Ribaric
May 5, 2005·Experimental Neurology·Fay B HorakJohn G Nutt
Jun 3, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Alan C BreenGert Bronfort
Aug 12, 2006·Neuroscience Letters·Laura RocchiFay B Horak
Mar 16, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Doris BroetzJoachim P Steinbach
Jul 3, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Simon BrumagneEge Suuden-Johanson
Oct 31, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anna FrenklachHelen Bronte-Stewart
Dec 23, 2008·Pain·A G BeiskeE Svensson
Jan 27, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Maarten J NijkrakeMarten Munneke
Jul 14, 2009·Journal of Motor Behavior·Jürgen KonczakMatthias Maschke
Aug 4, 2009·Annals of the New York Academy of Sciences·Fay B Horak
Jan 15, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jesse V JacobsKeith J Nagle
Jul 6, 2010·Experimental Neurology·W G WrightF B Horak
Aug 31, 2010·Archives of Physical Medicine and Rehabilitation·Angela S LeeLawrence W Mysliwiec
Dec 21, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Roberto Cano-de-la-CuerdaElena Muñoz-Hellín
Dec 28, 2010·Human Movement Science·T W CacciatoreK E Ames
Sep 29, 2011·Journal of Neuroengineering and Rehabilitation·Veronica CimolinPaolo Capodaglio
Nov 22, 2011·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Stephanie L JonesJanice Y Bunn
Jun 5, 2012·Journal of the Neurological Sciences·Katerina FarnikovaPetr Kanovsky
Jul 4, 2012·Nature Neuroscience·Marwan N BalikiA Vania Apkarian
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Fay B Horak, Martina Mancini
Nov 23, 2013·Parkinsonism & Related Disorders·Marjolein A van der Marck, Bastiaan R Bloem

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Citations

Oct 8, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Anat V LubetzkyYoussef Masharawi

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