What interventions are effective in improving uptake and retention of HIV-positive pregnant and breastfeeding women and their infants in prevention of mother to child transmission care programmes in low-income and middle-income countries? A systematic review and meta-analysis

BMJ Open
Lisa M Puchalski Ritchiethe PURE consortium

Abstract

This review was conducted to identify interventions effective in improving uptake and retention of HIV-positive mothers and their infants in prevention of mother to child transmission (PMTCT) services in low-income and middle-income countries (LMICs) in order to inform programme planning. We conducted a systematic review of studies comparing usual care with any intervention to improve uptake and retention of HIV-positive pregnant or breastfeeding women and their children from birth to 2 years of age in PMTCT services in LMICs. Twenty-two electronic databases were searched from inception to 15 January 2018, for randomised, quasi-randomised and non-randomised controlled trials, and interrupted time series studies; reference lists of included articles were searched for relevant articles. Risk of bias was assessed using the Cochrane Effective Practice and Organisation of Care group criteria. Random-effects meta-analysis was conducted for studies reporting similar interventions and outcomes. We identified 29 837 articles, of which 18 studies were included in our review. Because of heterogeneity in interventions and outcome measures, only one meta-analysis of two studies and one outcome was conducted; we found a statistically signifi...Continue Reading

References

Feb 24, 2009·Journal of Clinical Epidemiology·Margaret SampsonCarol Lefebvre
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Mar 26, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mary Pat KiefferCatherine M Wilfert
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Serena BrusamentoJosip Car
Jun 20, 2013·Journal of the International Association of Providers of AIDS Care·Stephen M WeissDeborah L Jones
Apr 16, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alison Silvis RustagiUNKNOWN with input from the SAIA Study Team
Apr 28, 2016·Journal of the International AIDS Society·Pascal GeldsetzerTill Bärnighausen

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Citations

Sep 21, 2020·European Journal of Public Health·Elizabeth J KingJulia Godunova

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