What investigations are needed to optimally monitor for malignancies in SLE?

Lupus
B Tessier-CloutierS Bernatsky

Abstract

The overall cancer incidence risk in systemic lupus erythematosus (SLE) is approximately 15%-20% more than in the general population. Nevertheless, to date, the optimal malignancy screening measures in SLE remain undefined. Our objective is to determine what investigations are needed to optimally monitor for malignancies in SLE in order to inform upcoming Canadian Rheumatology Association recommendations. We conducted a systematic search looking at three scientific sources, Embase, Medline and Cochrane, in an attempt to identify cancer screening recommendations for patients with SLE. We used a filter for observational studies and included articles published in 2000 and onward. The initial search strategy led to 986 records. After removal of duplicates and articles unrelated to SLE, we were left with 497 titles. From those, 79 research articles on cancer incidence in SLE were isolated and reviewed. Of the 79 original research papers, 25 offered screening recommendations, 14 suggested additional cancer screening whereas 11 studies simply promoted adherence to general population screening measures. The suggestions for more rigorous screening included recommending human papilloma virus testing in addition to routine cervical screen...Continue Reading

References

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Citations

Jan 6, 2016·Indian Journal of Pediatrics·Sujata Sawhney
Sep 6, 2018·Expert Review of Clinical Immunology·Alexandra LadouceurAnn E Clarke
Jan 18, 2018·The Journal of Rheumatology·Sasha BernatskyAnn E Clarke
Dec 20, 2018·RMD Open·Farah TamirouNathalie Costedoat-Chalumeau
Dec 26, 2016·Rheumatology·Bernard Thong, Nancy J Olsen
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·May Y ChoiAnn E Clarke

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Methods Mentioned

BETA
biopsies

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