What is an RNA? A top layer for RNA classification

RNA Biology
Jürgen Brosius, Carsten A Raabe

Abstract

Every ribonucleic acid begins its cellular life as a transcript. If the transcript or its processing product has a function it should be regarded an RNA. Nonfunctional transcripts, by-products from processing, degradation intermediates, even those originating from (functional) RNAs, and non-functional products of transcriptional gene regulation accomplished via the act of transcription, as well as stochastic (co)transcripts could simply be addressed as transcripts (class 0). The copious functional RNAs (class I), often maturing after one or more processing steps, already are systematized into ever expanding sub-classifications ranging from micro RNAs to rRNAs. Established sub-classifications addressing a wide functional diversity remain unaffected. mRNAs (class II) are distinct from any other RNA by virtue of their potential to be translated into (poly)peptide(s) on ribosomes. We are not proposing a novel RNA classification, but wish to add a basic concept with existing terminology (transcript, RNA, and mRNA) that should serve as an additional framework for carefully delineating RNA function from an avalanche of RNA sequencing data. At the same time, this top level hierarchical model should illuminate important principles of RN...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J Brosius, S J Gould
Jan 1, 1989·Bulletin of Mathematical Biology·E N Trifonov
Dec 1, 1968·Journal of Molecular Biology·R A Weinberg, S Penman
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·T TensonA Mankin
Mar 19, 2002·Genome Biology·Flavio MignoneGraziano Pesole
Mar 23, 2002·Cell·Melissa J Moore
Jan 25, 2003·Experimental Gerontology·Michelangela BarbieriGiuseppe Paolisso
Mar 19, 1965·Science·R W HOLLEYA ZAMIR
Sep 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John S Mattick
Apr 27, 2005·Trends in Genetics : TIG·Jürgen Brosius
Jun 1, 2005·Trends in Genetics : TIG·Keith E ShearwinJ Barry Egan
Oct 19, 2005·The Journal of Biological Chemistry·Jerard Hurwitz
Apr 4, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Travis BaughanChristian L Lorson
Dec 21, 2006·RNA Biology·Jürgen Brosius, Henri Tiedge
Feb 6, 2007·Nature Structural & Molecular Biology·Kevin Struhl
Feb 10, 2007·BMC Evolutionary Biology·Hui Chen, Mathieu Blanchette
Mar 27, 2007·Current Opinion in Microbiology·Paul Babitzke, Tony Romeo
Jun 15, 2007·Genome Research·Thomas R Gingeras
Jul 24, 2007·Nature Genetics·José Manuel Franco-ZorrillaJavier Paz-Ares
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Caryn S Wadler, Carin K Vanderpool
Oct 30, 2008·Cell·Arjun Raj, Alexander van Oudenaarden
Dec 2, 2008·PLoS Computational Biology·Marcel E DingerJohn S Mattick
Jan 27, 2009·Nature·Zhenyu XuLars M Steinmetz
Jun 3, 2009·Genes & Development·Patricia Richard, James L Manley
Nov 17, 2009·FEBS Letters·Christopher S Hayes, Kenneth C Keiler
Nov 26, 2009·Genes & Development·Yong Sun LeeAnindya Dutta
Jan 8, 2010·Human Molecular Genetics·Shivendra KishoreStefan Stamm
Mar 10, 2010·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Piero Carninci
May 27, 2010·PLoS Biology·Harm van BakelTimothy R Hughes
Nov 30, 2010·Biochimie·Damien UlvelingFlorent Hubé
Jul 19, 2011·PLoS Biology·Michael B ClarkJohn S Mattick
Jul 27, 2011·Biochimie·Jürgen Schmitz, Jürgen Brosius
Sep 29, 2011·Genome Biology and Evolution·Benjamin A Wilson, Joanna Masel
Oct 18, 2011·Journal of Theoretical Biology·Dmitrii Polev
Feb 18, 2012·Nature·Monika S KowalczykThomas R Gingeras
Apr 27, 2012·Frontiers in Genetics·Philipp Kapranov, Georges St Laurent
Aug 18, 2012·Plant Signaling & Behavior·Isaac R BanksSergey Ivashuta
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium

❮ Previous
Next ❯

Citations

Jun 29, 2016·Scientific Reports·Thomas RobeckJürgen Brosius
Jan 9, 2018·Nucleic Acids Research·Amit PandeCarsten A Raabe
Mar 23, 2017·Journal of Extracellular Vesicles·Bogdan MateescuEsther N M Nolte-'t Hoen
Nov 1, 2016·Journal of Cheminformatics·Stuart J Chalk
Feb 23, 2020·Biomolecules·Younghoon LeeHeegwon Shin
Sep 22, 2020·RNA Biology·Mauno Vihinen
May 26, 2018·Critical Reviews in Biochemistry and Molecular Biology·Hong-Leong CheahThean-Hock Tang
Feb 25, 2019·Science China. Life Sciences·Jürgen Brosius
Dec 15, 2020·Current Opinion in Organ Transplantation·Elly VarmaThangamani Muthukumar
Feb 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Meng-Nan LiuHua Zhou
Mar 24, 2021·Annual Review of Plant Biology·Andrzej T WierzbickiSzymon Swiezewski
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarva KeihaniEugenio F Fornasiero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemical Society Symposium
U E Loening
Proceedings of the National Academy of Sciences of the United States of America
A P Grollman, M L Stewart
Journal of Molecular Biology
G N Dessev, K Grancharov
© 2021 Meta ULC. All rights reserved