What is hormesis and its relevance to healthy aging and longevity?

Biogerontology
Edward J CalabreseVittorio Calabrese

Abstract

This paper provides a broad overview of hormesis, a specific type of biphasic dose response, its historical and scientific foundations as well as its biomedical applications, especially with respect to aging. Hormesis is a fundamental component of adaptability, neutralizing many endogenous and environmental challenges by toxic agents, thereby enhancing survival. Hormesis is highly conserved, broadly generalizable, and pleiotrophic, being independent of biological model, endpoint measured, inducing agent, level of biological organization and mechanism. The low dose stimulatory hormetic response has specific characteristics which defines both the quantitative features of biological plasticity and the potential for maximum biological performance, thereby estimating the limits to which numerous medical and pharmacological interventions may affect humans. The substantial degrading of some hormetic processes in the aged may profoundly reduce the capacity to respond effectively to numerous environmental/ischemic and other stressors leading to compromised health, disease and, ultimately, defining the bounds of longevity.

References

Aug 11, 1989·Science·L A Sagan
Aug 11, 1989·Science·S Wolff
May 1, 1987·Health Physics·A R Stebbing
Dec 1, 1987·Regulatory Toxicology and Pharmacology : RTP·B N Ames
May 1, 1987·Health Physics·E J CalabreseE Kenyon
Apr 17, 1987·Science·B N AmesL S Gold
Oct 1, 1972·Journal of Medical Education·M P Coulter
Feb 1, 1982·The Science of the Total Environment·A R Stebbing
Mar 1, 1996·The Annals of Thoracic Surgery·P G BurnsS Levitsky
Jun 1, 1996·Journal of the American College of Cardiology·P AbeteF Rengo
Feb 19, 1998·Experimental Gerontology·E J Masoro
Sep 3, 1998·Mutation Research·A R Stebbing
Feb 4, 1999·The Annals of Thoracic Surgery·J D McCullyS Levitsky
Mar 3, 1999·Ecotoxicology and Environmental Safety·E J Calabreseci
Sep 14, 1999·Journal of the American Geriatrics Society·C NapoliP Abete
Apr 4, 2000·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Apr 4, 2000·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Apr 4, 2000·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Apr 4, 2000·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Apr 4, 2000·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G LongobardiF Rengo
Jun 1, 2000·Experimental Gerontology·E J Masoro
Jun 22, 2000·Journal of Molecular and Cellular Cardiology·R A FentonJ G Dobson
Aug 10, 2000·Journal of the American College of Cardiology·P AbeteF Rengo
Dec 21, 2000·Cardiovascular Research·S Pepe
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese, L A Baldwin
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Nov 16, 2001·Biogerontology·E J Calabrese, L A Baldwin
Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James R Cypser, Thomas E Johnson
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Pasquale AbeteFranco Rengo
May 22, 2002·Journal of the American College of Cardiology·Pasquale AbeteFranco Rengo

❮ Previous
Next ❯

Citations

Aug 16, 2016·Ageing Research Reviews·Alexander M VaisermanAlexander K Koliada
Apr 7, 2016·International Journal of Aging & Human Development·Mai StaffordDiana Kuh
Jan 5, 2017·The FEBS Journal·Sharadha Dayalan Naidu, Albena T Dinkova-Kostova
Apr 9, 2017·Biogerontology·Debarati ChattopadhyayKavitha Thirumurugan
Jun 9, 2017·Nutrition Reviews·Morena MartucciAurelia Santoro
Jul 1, 2017·Annals of the New York Academy of Sciences·Andrey S MarchevMilen I Georgiev
Jun 24, 2017·Antioxidants & Redox Signaling·Maria Valeria CataniMauro Maccarrone
Feb 15, 2018·Medicines·Hiroshi Sakagami, Mineko Tomomura
Nov 22, 2017·International Journal of Radiation Biology·Paul N Schofield, Monika Kondratowicz
May 19, 2018·International Journal of Radiation Biology·Ki Moon SeongYoung Woo Jin
Jul 18, 2018·BioTechniques·Fan LiXingbo Lu
Jul 18, 2018·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Jan 25, 2020·Aging·Pilar DongilCarmen Sanz
Aug 17, 2020·ELife·Chaitanya A KulkarniPaul S Brookes
Nov 7, 2015·Immunity & Ageing : I & a·Sandro DattiloVittorio Calabrese
Aug 3, 2017·Experimental Physiology·Thomas B L Kirkwood
May 16, 2018·Dose-response : a Publication of International Hormesis Society·Juana Rosado-Pérez, Víctor Manuel Mendoza-Núñez
Sep 29, 2018·Dose-response : a Publication of International Hormesis Society·Alexander VaisermanYehoshua Socol
Oct 19, 2019·Archives of Insect Biochemistry and Physiology·Shijiao XiongGongyin Ye
Apr 5, 2020·International Journal of Molecular Sciences·Ines AmaraVittorio Calabrese
Jun 21, 2020·Biogerontology·Georges E Janssens, Riekelt H Houtkooper
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Pedro Posadas-RodríguezArmando Luna-López
Oct 19, 2016·Journal of Neuroscience Research·Vittorio CalabreseEdward J Calabrese
Nov 20, 2016·Journal of Neuroscience Research·Manuela PennisiVittorio Calabrese
Aug 12, 2018·Journal of Neuroscience Research·Vittorio CalabreseEdward J Calabrese
Mar 20, 2020·Biogerontology·Vittoria de Lima CamandonaJose Ribamar Ferreira-Junior
Aug 28, 2020·Frontiers in Medicine·Marios Kyriazis
Oct 19, 2016·Journal of Neuroscience Research·V CalabreseE J Calabrese
Apr 19, 2017·ELife·Youlian GoulevGilles Charvin
Jan 30, 2018·Frontiers in Immunology·Tamas FulopClaudio Franceschi
Dec 11, 2020·ELife·Hillary A MillerScott F Leiser
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Yongli YeXiulan Sun
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingyi ZhangVenkat Venkataraman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

© 2021 Meta ULC. All rights reserved