What is responsible for the carcinogenicity of PM2.5?

Occupational and Environmental Medicine
Roy M HarrisonA J Kibble

Abstract

To test whether exposure to known chemical carcinogens in the atmosphere is capable of explaining the association between concentrations of PM2.5 and lung cancer mortality observed in the extended ACS Cohort Study. Taking account of possible cancer latency periods, lung cancer rates due to exposure to As, Cr(VI), Ni, and polycyclic aromatic hydrocarbons (PAHs) were calculated based on a review of historic measurements from the United States and the use of unit risk factors. The predicted rates were compared with rates of cancer attributable to PM2.5 derived from data in the ACS study. Despite many uncertainties, the lung cancer rates predicted due to exposure to US urban concentrations of the carcinogenic substances arsenic, nickel, chromium, and PAHs measured in 1960 and earlier (and hence allowing for a latency period) were within the range predicted on the basis of the ACS Cohort Study due to exposure of PM2.5. There are, however, many caveats, most particularly that for the chemical carcinogens to be responsible for the effects attributed to PM2.5 by Pope and colleagues, the concentrations of chemical carcinogens at the time of relevant exposures would need to be correlated with the concentrations of PM2.5 in US urban areas...Continue Reading

References

Mar 11, 1975·Atmospheric Environment·G Gartrell, S K Friedlander
Mar 1, 1991·Journal of the Air & Waste Management Association·D M GloverD R D'Auben
Jun 1, 1988·The Science of the Total Environment·R B Hayes
Aug 1, 1967·Archives of Environmental Health·R M HagstromE Landau
Mar 1, 1970·Journal of the Air Pollution Control Association·T J KneipP C Freudenthal
Oct 16, 1970·Science·G B MorganE C Tabor
Feb 1, 1966·Journal of the Air Pollution Control Association·L DeMaio, M Corn
Mar 1, 1993·Clinics in Chest Medicine·W S Beckett
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·D M ManninoM Thun
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Mar 21, 2002·Clinics in Chest Medicine·Kathryn Smith BilelloRichard A Matthay
Jul 18, 2002·Inhalation Toxicology·Günter Oberdörster
Jan 11, 2003·Environmental Science & Technology·Robert J KieberSuzanne D Zvalaren
Apr 24, 2003·Occupational and Environmental Medicine·K Donaldson
Jul 12, 2003·Journal of Occupational and Environmental Medicine·Martin RöösliCharlotte Braun-Fahrländer
Dec 1, 1960·American Industrial Hygiene Association Journal·E SAWICKIT W STANLEY

❮ Previous
Next ❯

Citations

May 1, 2010·Reviews on Environmental Health·William L Chameides
May 10, 2012·Journal of Occupational and Environmental Medicine·Kari PasanenPia K Verkasalo
Sep 21, 2010·Journal of Hazardous Materials·Byeong-Kyu Lee, Gee-Hyeong Park
Nov 23, 2006·Annals of the New York Academy of Sciences·Mathuros RuchirawatHerman Autrup
Nov 23, 2006·Annals of the New York Academy of Sciences·Pietro CombaUNKNOWN Health Impact of Waste Management Campania Working Group
Jun 12, 2014·International Journal of Cancer. Journal International Du Cancer·Christopher KimQing Lan
Aug 7, 2012·Inhalation Toxicology·Manuela CiarroccaAngela Sancini
May 6, 2016·Environmental Science and Pollution Research International·Benjamin A Musa BandoweKinfai Ho
Aug 21, 2016·Environmental Pollution·Andrea CattaneoDomenico Maria Cavallo
Dec 16, 2006·The Science of the Total Environment·Eléna NerriereDenis Zmirou-Navier
Mar 16, 2018·Cancer Medicine·Yue ZhangMin Dai
Jan 13, 2009·Journal of Environmental Monitoring : JEM·Rodolfo CucchiellaClaudio Trombini
Jun 5, 2012·Chemical Society Reviews·Mathew R HealRoy M Harrison
Jul 25, 2019·International Journal of Environmental Research and Public Health·Monika ŚciborGrazyna Jasienska
Sep 26, 2019·Frontiers in Medicine·Takanori HidakaSetsuya Aiba
Mar 2, 2017·Cancer Causes & Control : CCC·Vikki HoAnita Koushik
Jun 24, 2017·International Journal of Environmental Research and Public Health·Amit U RaysoniWen-Whai Li
Jan 1, 2016·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Sinan SousanThomas M Peters
May 15, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Judy Y OuAnne C Kirchhoff
Nov 7, 2020·International Journal of Environmental Research and Public Health·Ariane MbemiPaul B Tchounwou
Mar 18, 2021·Seminars in Cancer Biology·Halina WasClaudine Kieda
Mar 23, 2021·Archives of Environmental & Occupational Health·Raphael Mendonça GuimarãesDaniela Buosi Rohlfs
Apr 20, 2021·Environment International·Joanne E SordilloDiane R Gold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.