What is slow axonal transport?

Experimental Cell Research
Kyle E Miller, Steven R Heidemann

Abstract

While the phenomenon of slow axonal transport is widely agreed upon, its underlying mechanism has been controversial for decades. There is now persuasive evidence that several different mechanisms could contribute to slow axonal transport. Yet proponents of different theories have been hesitant to explicitly integrate what were, at least initially, opposing models. We suggest that slow transport is a multivariate phenomenon that arises through mechanisms that minimally include: molecular motor-based transport of polymers and soluble proteins as multi-protein complexes; diffusion; and en bloc transport of the axonal framework by low velocity transport and towed growth (due to increases in body size). In addition to integrating previously described mechanisms of transport, we further suggest that only a subset of transport modes operate in a given neuron depending on the region, length, species, cell type, and developmental stage. We believe that this multivariate approach to slow axonal transport better explains its complex phenomenology: including its bi-directionality; the differing velocities of transport depending on cargo, as well differing velocities due to anatomy, cell type and developmental stage.

References

Jan 1, 1992·Current Topics in Cellular Regulation·H R Knull, J L Walsh
Oct 1, 1991·The Journal of Cell Biology·S S ReinschM Kirschner
Jul 1, 1990·The Journal of Cell Biology·S S LimG G Borisy
Jan 1, 1990·Cell Motility and the Cytoskeleton·S R Heidemann, R E Buxbaum
Jan 1, 1989·Cell Motility and the Cytoskeleton·J J Blum, M C Reed
Feb 7, 1985·Journal of Theoretical Biology·J Alvarez, J C Torres
Jun 19, 1986·Nature·J R BamburgK Chapman
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M WillardP R Vagelos
Mar 1, 1974·Experimental Neurology·M Murray
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D Bray
May 1, 1980·The Journal of Cell Biology·D J Fink, H Gainer
Oct 1, 1980·Physiological Reviews·B Grafstein, D S Forman
Jul 1, 1984·The Journal of Cell Biology·R J LasekS T Brady
Aug 1, 1981·Journal of Neurocytology·D Bray, M B Bunge
Jun 1, 1995·Neuron·J SabryM W Kirschner
Apr 1, 1995·Journal of Neurochemistry·S L TannerG D Bittner
Mar 1, 1994·Bulletin of Mathematical Biology·M P Van Veen, J Van Pelt
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·M TerasakiT S Reese
Feb 1, 1997·Current Opinion in Cell Biology·P W Baas
Jun 7, 1997·Journal of Theoretical Biology·K E Miller, D C Samuels
Nov 17, 1999·The European Journal of Neuroscience·P H JensenC G Dotti
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E L BearerJ H LaVail

❮ Previous
Next ❯

Citations

Mar 6, 2010·BMC Neuroscience·Jacqueline A SobotaRichard E Mains
Apr 30, 2011·Progress in Neurobiology·Daniel M Suter, Kyle E Miller
Nov 3, 2009·Progress in Neurobiology·Ian N M Day, Rod J Thompson
Aug 12, 2009·Progress in Neurobiology·Douglas H Smith
Mar 13, 2015·Biophysical Journal·Matthew O'TooleKyle E Miller
Jun 19, 2014·Biophysical Journal·Matan MusselUri Nevo
Aug 21, 2013·Developmental Neurobiology·Laura F GumyCasper C Hoogenraad
Jan 20, 2011·Biophysical Journal·Matthew O'Toole, Kyle E Miller
Jun 24, 2014·Journal of Theoretical Biology·S DiehlS Perna
Jul 28, 2012·Journal of Neurogenetics·Aparna Sadananda, Krishanu Ray
Feb 24, 2015·Frontiers in Medicine·Arun ChaudhuryJacqueline Nelisis Zanoni
Apr 29, 2016·Journal of Computational Neuroscience·Stefan DiehlAnders Heyden
Aug 12, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matan MusselUri Nevo
Oct 19, 2016·Cytoskeleton·Rodrigo López-LealFelipe A Court
Oct 8, 2013·PloS One·T Lynne BlasiusKristen J Verhey
Aug 30, 2012·Nature Communications·Yan GuNing Fang
Sep 9, 2017·Developmental Neurobiology·Eugene Jennifer JinPeter Robin Hiesinger
Feb 8, 2018·Biologie aujourd'hui·Marie Anne Breau, Sylvie Schneider-Maunoury
Aug 4, 2020·Neural Development·Vivian T ChouDavid Van Vactor
Jul 15, 2020·Physical Biology·Saurabh S MogreElena F Koslover

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Subhojit RoyVirginia M-Y Lee
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Subhojit RoyVirginia M-Y Lee
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Niraj TrivediA Brown
Journal of Theoretical Biology
Gheorghe CraciunAvner Friedman
© 2022 Meta ULC. All rights reserved