What is the best management strategy for a 20-year-old woman with premature ovarian failure?

Clinical Endocrinology
Melanie C Davies, B Cartwright

Abstract

The diagnosis of premature ovarian failure (POF) for a 20-year-old woman is devastating and will impact on many areas of her life. She deserves prompt confirmation of the diagnosis and accurate, honest information about the condition including the chances of conception and long-term health issues. She should be offered investigation of aetiology, although this may be hard to establish, and assessment of associated medical conditions. Oestrogen replacement should be advised for long-term use until the normal age of menopause, and she should be fully counselled on the benefits and risks of hormone replacement and her options of which preparation to take. Long-term follow-up is needed, and this is likely to require multidisciplinary input, including that from a gynaecologist, clinical psychologist and fertility team. POF may not be the appropriate terminology for this condition. Ovarian function often fluctuates in young women with POF, who may continue to menstruate occasionally and even conceive spontaneously. In view of this unpredictability, 'premature ovarian insufficiency' is a better description of the condition and carries a less negative connotation than 'ovarian failure' which can cause great distress. We recommend that ...Continue Reading

References

May 1, 1992·British Journal of Obstetrics and Gynaecology·K MünsterL Schmidt
Feb 1, 1996·Fertility and Sterility·G S ConwayH S Jacobs
Dec 1, 1995·Clinical Endocrinology·M C DaviesH S Jacobs
Aug 27, 1998·Journal of Medical Genetics·A MurrayP Jacobs
Mar 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J LuborskyR Pong
Nov 15, 2000·Journal of Psychosomatic Obstetrics and Gynaecology·K L LiaoG S Conway
Jul 14, 2001·American Journal of Medical Genetics·S L Sherman
Apr 30, 2002·Obstetrics and Gynecology·Nahrain H AlzubaidiLawrence M Nelson
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D J M van Der VoortR Barentsen
Jun 14, 2005·Epidemiology·Marlies E OssewaardeYvonne T van der Schouw
Jul 12, 2005·Archives of Gynecology and Obstetrics·Dilek UygurLeyla Mollamahmutoglu
Nov 9, 2005·Fertility and Sterility·Emily C CorriganLawrence M Nelson
Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Janet B HenrichLester R Curtin
Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Femke AtsmaYvonne T van der Schouw
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Ravinder GoswamiSatveer Singh
Nov 16, 2006·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
Apr 24, 2007·Menopause International·Joan PitkinJennifer Williamson
Oct 27, 2007·Fertility and Sterility·Sophia N KalantaridouLawrence M Nelson
Feb 8, 2008·Menopause : the Journal of the North American Menopause Society·Jolande G van der StegeAnnemieke Hoek
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Jul 29, 2008·Current Opinion in Obstetrics & Gynecology·Maud BidetPhilippe Touraine
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Erik A H KnauffUNKNOWN Dutch Premature Ovarian Failure Consortium
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Vaishali B PopatLawrence M Nelson
May 26, 2009·Menopause International·Svetlana Vujovic
May 27, 2011·The Journal of Clinical Endocrinology and Metabolism·S L BroerF J M Broekmans

❮ Previous
Next ❯

Citations

Jan 25, 2019·Aging·Jinjin ZhangShixuan Wang
Jul 12, 2017·Human Reproduction Open·Lisa WebberNathalie Vermeulen
Dec 3, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Helena GiraldoPaulo Giraldo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
B CartwrightJ Rymer
Hormone Research
Deepti Goswami, Gerard S Conway
Best Practice & Research. Clinical Obstetrics & Gynaecology
N Panay, Emmanuel Kalu
© 2021 Meta ULC. All rights reserved