PMID: 8964186Feb 1, 1996Paper

What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?

Diabetes Research and Clinical Practice
R Bucala

Abstract

Reducing sugars such as glucose react non-enzymatically with the amino groups of proteins and lipids to initiate a chemical modification pathway known as advanced glycosylation. Recent progress in our understanding of this process has affirmed the hypothesis that advanced glycosylation endproducts (AGEs) play an important role in the evolution of both diabetic and non-diabetic vascular disease. Utilizing newly developed AGE-specific ELISA techniques, AGEs have been identified to be present on a variety of vascular wall, lipoprotein, and lipid constituents. Vascular wall AGEs contribute to vascular pathology by acting to increase vascular permeability, enhance subintimal protein and lipoprotein deposition, and inactivate the endothelium-derived relaxing factor, nitric oxide. Lipid-linked AGEs also have been shown to initiate oxidative modification, thus promoting the formation of oxidized low-density lipoprotein. AGE-specific ELISA analysis has demonstrated a significantly increased level of AGE-modified LDL in the plasma of diabetic patients when compared to normal controls. Furthermore, LDL which has been modified by advanced glycosylation exhibits markedly impaired clearance kinetics in vivo. Thus, AGE-modification impairs LD...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·J L Goldstein, M S Brown
May 11, 1979·JAMA : the Journal of the American Medical Association·W B Kannel, D L McGee
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Jan 1, 1992·Advances in Pharmacology·R Bucala, A Cerami
Feb 1, 1991·International Journal of Radiation Biology·B H Bielski, D E Cabelli
Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraA Cerami
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Jan 1, 1987·Critical Reviews in Food Science and Nutrition·J KannerJ E Kinsella
Mar 1, 1984·Progress in Cardiovascular Diseases·N B Ruderman, C Haudenschild
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V M MonnierA Cerami
Jun 1, 1981·Biochemical Medicine·I NishigakiK Yagi
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Jan 1, 1994·The Medical Clinics of North America·W V Brown
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Jan 1, 1993·Chemical Research in Toxicology·T A Dix, J Aikens

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Citations

Jul 13, 1999·The Journal of Laboratory and Clinical Medicine·W A Oranje, B H Wolffenbuttel
Apr 30, 2009·Proteomics·Matthew R RichardsonFrank A Witzmann
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katharina Schreck, Matthias F Melzig
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Paolo MenèFrancesco Pugliese
Nov 15, 2000·Canadian Journal of Physiology and Pharmacology·J T Saari

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