What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
C G EllisDaniel Goldman

Abstract

Erythrocytes appear to be ideal sensors for regulating microvascular O(2) supply as they release the potent vasodilator ATP in an O(2) saturation-dependent manner. Whether erythrocytes play a significant role in regulating O(2) supply in the complex environment of diffusional O(2) exchange among capillaries, arterioles, and venules, depends on the efficiency with which erythrocytes signal the vascular endothelium. If one assumes that the distribution of purinergic receptors is uniform throughout the microvasculature, then the most efficient site for signaling should occur in capillaries, where the erythrocyte membrane is in close proximity to the endothelium. ATP released from erythrocytes would diffuse a short distance to P(2y) receptors inducing an increase in blood flow, possibly the result of endothelial hyperpolarization. We hypothesize that this hyperpolarization varies across the capillary bed depending upon erythrocyte supply rate and the flux of O(2) from these erythrocytes to support O(2) metabolism. This would suggest that the capillary bed would be the most effective site for erythrocytes to communicate tissue oxygen needs. Electrically coupled endothelial cells conduct the integrated signal upstream where arteriole...Continue Reading

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Citations

Oct 11, 2012·Journal of the International Society of Sports Nutrition·John A RathmacherRick L Sharp
May 30, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Donald G Welsh, Mark S Taylor
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Apr 19, 2015·Current Opinion in Pediatrics·Ahmed SaidAllan Doctor
Nov 6, 2015·Critical Care : the Official Journal of the Critical Care Forum·Ryon M BatemanChristopher G Ellis
Apr 15, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nour W GhonaimChristopher G Ellis
Jun 29, 2021·Frontiers in Physiology·Hao YinJ Geoffrey Pickering
Sep 22, 2021·Biophysical Journal·Zhe GouChaouqi Misbah

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