PMID: 9429729Jan 16, 1998Paper

What is the evidence that osteoarthritis is genetically determined?

Baillière's Clinical Rheumatology
F Cicuttini, T D Spector

Abstract

Although for many years it was speculated that osteoarthritis was genetically determined, little data were available to support this contention. A major problem with early work was a lack of consistency in the definition of osteoarthritis. Based on a radiographical definition of osteoarthritis, which is currently the optimal method for epidemiological and genetic studies, data from a recent twin study have provided an estimate of the hereditable component of osteoarthritis to be in the order of 50 to 65%. In addition, sophisticated molecular biology techniques are being increasingly used to explore potential genetic abnormalities in cartilage and matrix components in osteoarthritis. These exciting new data are examined as we address the role of genetic factors in osteoarthritis.

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Citations

Jan 2, 2004·Aging Clinical and Experimental Research·Maria Chiara Corti, Chiara Rigon
May 20, 2009·Der Radiologe·H ImhofS Trattnig
Jun 15, 2011·Best Practice & Research. Clinical Rheumatology·Lucy BusijaMarlene Fransen
Aug 5, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·G Bálint, B Szebenyi
Dec 5, 2002·Osteoarthritis and Cartilage·C LiessC-C Glüer
Jul 1, 2010·Acta Odontologica Scandinavica·Cecilia MagnussonTomas Magnusson
Jan 25, 2002·The Medical Journal of Australia·G J McColl

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