What is the fate of the refluxing contralateral kidney in children with multicystic dysplastic kidney?

The Journal of Urology
David C MillerJohn M Park

Abstract

We clarify the natural history of contralateral vesicoureteral reflux (VUR) in children with multicystic dysplastic kidney (MCDK), including its impact on long-term renal growth. We performed a retrospective cohort study of 75 patients with MCDK. The primary outcomes were resolution of contralateral VUR and long-term renal growth. The Kaplan-Meier method was used to compare time to spontaneous resolution based on VUR grade. Mixed regression models were used to compare longitudinal changes in sonographic renal length. Contralateral VUR was present in 19 of the 75 cases (26.4%) and was low grade (I-II) in 9. After a median followup of 4.4 years spontaneous resolution was more common in patients with grades I and II (89%) versus grades III and IV VUR (50%) (p = 0.14). Median time to resolution did not differ by grade (20.1 vs 31.3 months, p = 0.3). One child underwent ureteral reimplantation and no patients had hypertension or renal insufficiency. Mixed regression analysis demonstrated no significant difference in the annual increase in renal length based on VUR status (p >0.20). In the largest series to date of patients with MCDK and contralateral VUR we found that spontaneous resolution in a relatively short period can be antici...Continue Reading

References

Mar 1, 1984·AJR. American Journal of Roentgenology·D M RosenbaumR L Teele
Apr 1, 1995·The Journal of Urology·A A Selzman, J S Elder
Dec 1, 1993·The Journal of Urology·J Wacksman, L Phipps
Apr 1, 1997·The British Journal of Radiology·G T RottenbergR De Bruyn
Oct 7, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U JohnJ Misselwitz
Oct 25, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L R Feldenberg, N J Siegel

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Citations

May 10, 2006·Journal of Applied Genetics·Grazyna KrzemieńRenata Sekowska
May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David S HainsAndrew L Schwaderer
Aug 13, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aysel KiyakGonul Aydogan
Aug 12, 2008·International Urology and Nephrology·Marco ZaffanelloVassilios Fanos
Apr 22, 2009·Indian Journal of Pediatrics·Jitendra Kumar SinghK L Narasimhan
Jan 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michiel F SchreuderJoanna A E van Wijk
May 6, 2005·Archives of Disease in Childhood·H Narchi
Oct 1, 2007·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Sumit Dave, Antoine E Khoury
Apr 7, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Karen Psooy
Sep 5, 2008·Advances in Urology·Sumit Dave, Antoine E Khoury
May 31, 2014·Journal of Pediatric Urology·Serdar MoralıoğluIpek Kaplan Bulut
Jun 27, 2012·Clinical Biochemistry·Amira Peco-AntićGordana Miloševski-Lomić
Jul 27, 2011·The Journal of Urology·Jean G Hollowell, Barry A Kogan
Dec 6, 2006·The Urologic Clinics of North America·Katherine C Hubert, Jeffrey S Palmer
Jan 15, 2008·BJU International·Angelo J CambioEric A Kurzrock
Sep 6, 2006·The Journal of Urology·Bulent Onal, Barry A Kogan
Jun 2, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Aslihan KaraZehra Pinar Koc
Dec 4, 2019·Pediatrics in Review·Halima S JanjuaSangeeta Krishna
Jul 4, 2018·Archives of Disease in Childhood·Shiva ShankarSagarika Ray

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