What is the function of osteocalcin?

Journal of Oral Biosciences
Toshihisa Komori

Abstract

Osteocalcin is the most abundant non-collagenous protein in bone and is specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn-/-) mice demonstrated that osteocalcin inhibits bone formation, and serum uncarboxylated osteocalcin functions as a hormone that improves glucose metabolism, induces testosterone synthesis in the testes, and maintains muscle mass. Furthermore, the relationship between serum osteocalcin and glucose metabolism or cardiovascular risk in humans has been reported. However, new Ocn-/- mice exhibited different phenotypes. Bone volume, formation, and resorption were normal in the new Ocn-/- mice. The orientation of collagen fibers was parallel to the bone longitudinal direction and the size of apatite crystals was normal, but the c-axis of apatite crystals was random and bone strength was reduced in new Ocn-/- mice. Glucose metabolism, testosterone synthesis, and muscle mass were normal in new Ocn-/- mice. Exercise improved glucose metabolism and increased bone formation, leading to an increase in the serum osteocalcin level, which is a marker for bone formation. Contrary to previous findings, new Ocn-/- mice revealed that osteocalcin has no function in the regulation of bone q...Continue Reading

References

Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P V HauschkaP M Gallop
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P A PriceN Raman
Jul 1, 1989·Physiological Reviews·P V HauschkaC M Gundberg
Jan 1, 1982·Metabolic Bone Disease & Related Research·J MenanteauM W Neuman
Jan 1, 1983·Calcified Tissue International·G R Mundy, J W Poser
May 11, 1982·Biochemistry·P V Hauschka, S A Carr
Jan 1, 1982·The Journal of Cell Biology·J D MaloneA J Kahn
Feb 12, 1980·Biochemical and Biophysical Research Communications·P V Hauschka, A H Reddi
Oct 4, 1995·Biochemical and Biophysical Research Communications·M Sato, N Tada
Aug 1, 1996·Nature·P DucyG Karsenty
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·D W Stafford
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Jul 29, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jee-Aee ImSang-Hwan Kim
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Jose Manuel Fernández-RealJavier Ibañez
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Ippei KanazawaToshitsugu Sugimoto
Dec 10, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jenny M KindblomDan Mellström
Dec 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Dec 24, 2008·Journal of Molecular Endocrinology·Petrine WellendorphHans Bräuner-Osborne
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·N B KavukcuogluA B Mann
Aug 13, 2009·European Journal of Endocrinology·Mi ZhouWeiping Jia
Sep 4, 2009·The Journal of Clinical Investigation·Tatsuya YoshizawaGerard Karsenty
Sep 16, 2009·Annals of the New York Academy of Sciences·Franco LumachiGiovanni Luisetto
Sep 25, 2009·The American Journal of Clinical Nutrition·M Kyla SheaSarah L Booth
Dec 30, 2009·The Journal of Clinical Investigation·Marie-Therese RachedStavroula Kousteni
Feb 19, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I KanazawaT Sugimoto
Feb 22, 2011·Cell·Franck OuryGerard Karsenty
Mar 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Min PiL Darryl Quarles
Mar 26, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M IkiN Kurumatani
May 15, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S OkunoM Inaba
Sep 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Chunyan LuSulin Cheng
Nov 28, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takuya IshimotoYasuhiko Tabata
Jun 4, 2013·The Journal of Clinical Investigation·Franck OuryGerard Karsenty

❮ Previous
Next ❯

Citations

Feb 15, 2021·Journal of Oral Biosciences·Hayato OhshimaNorio Amizuka
Oct 16, 2020·International Journal of Molecular Sciences·Toshihisa Komori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.