What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? A meta-analysis of 23 cohort studies involving 486,608 recipients

BMC Nephrology
Xinmiao ShiJie Ding

Abstract

The magnitude effects of human leukocyte antigen (HLA) mismatching on post-transplant outcomes of kidney transplantation remain controversial. We aim to quantitatively assess the associations of HLA mismatching with graft survival and mortality in adult kidney transplantation. We searched PubMed, EMBASE and the Cochrane Library from their inception to December, 2016. Priori clinical outcomes were overall graft failure, death-censored graft failure and all-cause mortality. A total of 23 cohort studies covering 486,608 recipients were selected. HLA per mismatch was significant associated with increased risks of overall graft failure (hazard ratio (HR), 1.06; 95% confidence interval (CI), 1.05-1.07), death-censored graft failure (HR: 1.09; 95% CI 1.06-1.12) and all-cause mortality (HR: 1.04; 95% CI: 1.02-1.07). Besides, HLA-DR mismatches were significant associated with worse overall graft survival (HR: 1.12, 95% CI: 1.05-1.21). For HLA-A locus, the association was insignificant (HR: 1.06; 95% CI: 0.98-1.14). We observed no significant association between HLA-B locus and overall graft failure (HR: 1.01; 95% CI: 0.90-1.15). In subgroup analyses, we found recipient sample size and ethnicity maybe the potential sources of heterogenei...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 26, 2002·Kidney International·Sundaram HariharanChristopher P Johnson
Jan 25, 2005·Transplantation·Bengt FellströmUNKNOWN Assessment of Lescol in Renal Transplantation Study Investigators
Jun 21, 2007·Transplantation Proceedings·L F AriasA Barrientos
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V B AshbyA B Leichtman
May 25, 2012·Kidney International·Jennifer M DeVosSamir J Patel
Aug 7, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Mirjam LagingJoke I Roodnat
Jun 12, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J LynchJ L Platt
Jul 11, 2013·Current Opinion in Organ Transplantation·Caner Süsal, Gerhard Opelz
Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Oct 22, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Christophe LegendreFrank Martinez
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Dec 10, 2013·Transplantation Proceedings·E Gómez GómezM J Requena Tapia
Jul 11, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel AbramowiczEvi Nagler
Oct 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paolo FerrariKathryn J Tinckam
Nov 9, 2014·Transplantation Proceedings·M ZukowskiR Bohatyrewicz
Mar 15, 2015·Transplantation Proceedings·N BroedersP Vereerstraeten
Jun 22, 2015·Transplantation Proceedings·S TekinA Demirbas
Nov 14, 2015·Journal of the American College of Cardiology·Yun-Jiu ChengSu-Hua Wu
Jan 12, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A B MassieD L Segev

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Citations

Oct 1, 2020·Pediatric Transplantation·Luiza do Nascimento Ghizoni PereiraPaulo Cesar Koch-Nogueira
Oct 2, 2020·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJose M Martin-Villa
Oct 28, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Roman Reindl-SchwaighoferRainer Oberbauer
Oct 14, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Sandesh ParajuliJon S Odorico

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