What is the impact of systemic chemotherapy for lateral lymph nodes in patients with locally advanced low rectal cancer?

International Journal of Colorectal Disease
Atsushi OguraMasato Nagino

Abstract

Systemic chemotherapy (SC) before surgery is a potential treatment to improve survival in patients with advanced rectal cancer. However, the impact of SC on lateral lymph nodes (LLNs) remains unclear. A total of 78 patients with stage II/III low rectal cancer, who received 3-month oxaliplatin-based SC followed by LLN dissection (LLND) in principle, were analysed retrospectively. "Total lateral lymph node metastases (tLLNMs)" was defined as having either pathological LLNMs (pLLNMs) or lateral local recurrences (LLRs). Patients with the maximum short-axis size of LLNs ≥ 7 mm were classified into the swollen group (n = 21). In the total cohort, tLLNMs included 6 pLLNMs (7.7%) and 2 LLRs (2.6%). In the non-swollen group, no patients had pLLNMs, but one had LLR (1.8%). In the swollen group, pLLNMs and LLRs were detected in 6 (28.6%) and 1 (4.8%), respectively. The swollen group was an independent risk factor for tLLNMs (P < 0.001), leading to the significantly worse 5-year relapse-free survival (RFS) of 52.4% than the others. For patients without swollen LLNs, SC could allow for omission both of lateral irradiation and LLND. For patients with swollen LLNs, the lateral local control was favourable after SC and LLND without chemoradio...Continue Reading

References

Sep 1, 1982·American Journal of Surgery·K HojoY Moriya
Apr 3, 1997·The New England Journal of Medicine·UNKNOWN Swedish Rectal Cancer TrialN Wilking
Jan 1, 1997·International Journal of Colorectal Disease·O DworakA Hoffmann
Oct 29, 2000·Diseases of the Colon and Rectum·T TakahashiH Ohta
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Sep 15, 2006·The New England Journal of Medicine·Jean-François BossetUNKNOWN EORTC Radiotherapy Group Trial 22921
May 3, 2012·Annals of Surgery·Takashi AkiyoshiUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Feb 18, 2014·Annals of Surgical Oncology·Toshisada AibaMasato Nagino
Oct 23, 2014·The New England Journal of Medicine·Fotios LoupakisAlfredo Falcone
Jun 19, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Takeo SatoMasahiko Watanabe
Apr 7, 2017·Diseases of the Colon and Rectum·Soichiro IshiharaToshiaki Watanabe
Sep 9, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Committee
Nov 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OguraUNKNOWN Lateral Node Study Consortium
Nov 25, 2018·International Journal of Clinical Oncology·Akihiro TomidaUNKNOWN Of the Nagoya Surgical Oncology Group
Jun 17, 2019·International Journal of Clinical Oncology·Yojiro HashiguchiUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Sep 27, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yanhong DengJianping Wang
Oct 15, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik P ModestMichael Geissler
Jul 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

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