What is the impact of the ACE gene insertion/deletion (I/D) polymorphism on the clinical effectiveness and adverse events of ACE inhibitors?--Protocol of a systematic review

BMC Medical Genetics
Madlaina ScharplatzLucas M Bachmann

Abstract

The Angiotensin Converting Enzyme (ACE) insertion/deletion (I/D) polymorphism has received much attention in pharmacogenetic research because observed variations in response to ACE inhibitors might be associated with this polymorphism. Pharmacogenetic testing raises the hope to individualise ACE inhibitor therapy in order to optimise its effectiveness and to reduce adverse effects for genetically different subgroups. However, the extent of its effect modification in patients treated with ACE inhibitors remains inconclusive. Therefore our objective is to quantify the effect modification of the insertion/deletion polymorphism of the angiotensin converting enzyme gene on any surrogate and clinically relevant parameters in patients with cardiovascular diseases, diabetes, renal transplantation and/or renal failure. Systematic Review. We will perform literature searches in six electronic databases to identify randomised controlled trials comparing the effectiveness and occurrence of adverse events of ACE inhibitor therapy against placebo or any active treatment stratified by the I/D gene polymorphism. In addition, authors of trials, experts in pharmacogenetics and pharmaceutical companies will be contacted for further published or un...Continue Reading

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Citations

Oct 26, 2005·Current Controlled Trials in Cardiovascular Medicine·Madlaina ScharplatzLucas M Bachmann
Jan 1, 2009·Pharmacogenomics and Personalized Medicine·Christopher BaroneShaker A Mousa
Jun 26, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Fu-Mei ChungYau-Jiunn Lee
Nov 10, 2006·Annals of Human Biology·Maha RebaïAhmed Rebaï
Dec 12, 2018·PloS One·Khadeeja MunawarShamsul Haque
Jun 5, 2020·International Journal of Occupational Safety and Ergonomics : JOSE·Gonzalo BravoHéctor Castellucci
Dec 19, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Noel PabalanChatchai Muanprasat

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Methods Mentioned

BETA
PCR
in
genotyping

Software Mentioned

Biosis
Stata

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