What is the influence of hormone therapy on homocysteine and crp levels in postmenopausal women?

Clinics
Eli Marcelo LakrycEdmund Chada Baracat

Abstract

To evaluate the influence of estrogen therapy and estrogen-progestin therapy on homocysteine and C-reactive protein levels in postmenopausal women. In total, 99 postmenopausal women were included in this double-blind, randomized clinical trial and divided into three groups: Group A used estrogen therapy alone (2.0 mg of 17β-estradiol), Group B received estrogen-progestin therapy (2.0 mg of 17 β-estradiol +1.0 mg of norethisterone acetate) and Group C received a placebo (control). The length of treatment was six months. Serum measurements of homocysteine and C-reactive protein were carried out prior to the onset of treatment and following six months of therapy. After six months of treatment, there was a 20.7% reduction in homocysteine levels and a 100.5% increase in C-reactive protein levels in the group of women who used estrogen therapy. With respect to the estrogen-progestin group, there was a 12.2% decrease in homocysteine levels and a 93.5% increase in C-reactive protein levels. Our data suggested that hormone therapy (unopposed estrogen or estrogen associated with progestin) may have a positive influence on decreasing cardiovascular risk due to a significant reduction in homocysteine levels.

Citations

Apr 2, 2016·Neurodegenerative Disease Management·Francesco BonettiGiovanni Zuliani
May 24, 2016·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·X SongC Liu
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Victoria L StevensSusan M Gapstur

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BETA
hysterectomy

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