Abstract
The rationale for anti-tumour necrosis factor-alpha (anti-TNFalpha) therapy in rheumatoid arthritis (RA) is based on experiments on cultures of human rheumatoidjoint tissue, supported by experiments in animal models, all of which demonstrated that anti-TNFalpha antibody had profound effects on the disease activity. Clinical trials have substantiated this concept, and we have used the serum samples from the clinical trials, as well as biopsies to study the changes occurring during anti-TNFalpha therapy as clues to the pathogenesis of RA. The major effects of anti-TNFalpha therapy are in downregulating cytokine activity, and in reducing leucocyte trafficking to the joints.
Citations
Oct 19, 1999·Arthritis and Rheumatism·M M MauriceC L Verweij
Dec 25, 2003·Archives of Oral Biology·Junji UeharaHirofumi Yatani
Nov 5, 2003·Cytokine·Midori MisumiYoshiaki Ishigatsubo
Dec 12, 2001·Clinical and Experimental Immunology·L D SpargoG Mayrhofer
May 14, 2004·Annals of the Rheumatic Diseases·R NissinenO Vaarala
Dec 1, 1999·Annals of the Rheumatic Diseases·C K Edwards
Jun 2, 2000·Annals of the Rheumatic Diseases·A K UlfgrenU Andersson
Jan 13, 2001·Annals of the Rheumatic Diseases·L BergL Klareskog
Jun 19, 2001·Annals of the Rheumatic Diseases·P BarreraW B van den Berg
Jul 2, 2004·Arthritis Research & Therapy·Sergio SchwartzmanG James Morgan
May 15, 2004·Arthritis Research & Therapy·Maung-Maung ThwinPonnampalam Gopalakrishnakone
Sep 22, 2009·Arthritis Research & Therapy·Maung-Maung ThwinPonnampalam Gopalakrishnakone
Dec 8, 2006·Expert Opinion on Biological Therapy·Carlo B Ramirez, Ignazio R Marino
Jul 24, 2015·Scandinavian Journal of Rheumatology·L Belenska-TodorovaN Ivanovska
Jun 22, 2010·Phytotherapy Research : PTR·Soo-Jin JeongSung-Hoon Kim
Mar 29, 2014·Clinical and Experimental Immunology·P ConigliaroR Perricone
Dec 15, 2007·Clinical Neuroscience Research·Adrian J Dunn
May 21, 2013·International Immunopharmacology·Geun-Hee LeeEun-Yi Moon
Jul 11, 2008·Molecular Medicine·Chunyu LiuPeter K Gregersen
Sep 1, 1997·Molecular Pharmacology·R E ShackelfordS Pizzo
Dec 26, 2001·European Journal of Immunology·Massimo TriggianiGianni Marone
May 9, 1998·Infection and Immunity·H S ElzaimJ P Heggers